Technology Process of Benzo(a)pyrene, 12b,12c-dihydro-12b,12c-dimethyl-, trans-
There total 15 articles about Benzo(a)pyrene, 12b,12c-dihydro-12b,12c-dimethyl-, trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / NBS
2: 71 percent / Br2 / CHCl3 / 2 h / Heating
3: 85 percent / methanol; dimethylformamide / 3 h / Heating
4: 82 percent / various solvent(s) / 18 h / 180 °C
5: 1.) diisobutylaluminuim hydride, 2.) aq. HCl / 1.) hexane-benzene, 20 deg C, 3 h, 2.) MeOH-H2O
6: 95 percent / NaBH4 / tetrahydrofuran / 20 °C
7: 89 percent / 48percent aq. HBr / 4 h / Heating
8: KOH / tetrahydrofuran; H2O; ethanol / 70 h
9: 1.) n-BuLi, 3.) (CH3O)2CHBF4, 4.) KO-t-Bu / 1.) THF, hexane, 0 deg C, 3 min, 3.) CH2Cl2, -30 deg C, 4 h, 4.) THF, 0 deg C, 30 min
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; potassium tert-butylate; hydrogen bromide; bromine; diisobutylaluminium hydride; dimethoxymethylium tetrafluoroborate;
In
tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00373a036
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 45 percent / 1.) n-BuLi / diethyl ether; benzene / 1.) reflux, 1 h, 2.) reflux, 1.5 h
2: 96 percent / PBr3 / diethyl ether / 24 h
3: 15 percent / N-bromosuccinimide / CCl4 / 5 h
4: KOH / tetrahydrofuran; H2O; ethanol / 70 h
5: 1.) n-BuLi, 3.) (CH3O)2CHBF4, 4.) KO-t-Bu / 1.) THF, hexane, 0 deg C, 3 min, 3.) CH2Cl2, -30 deg C, 4 h, 4.) THF, 0 deg C, 30 min
With
potassium hydroxide; N-Bromosuccinimide; n-butyllithium; potassium tert-butylate; phosphorus tribromide; dimethoxymethylium tetrafluoroborate;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; benzene;
DOI:10.1021/ja00373a036
