1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester

Base Information

• Chemical Name: 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester
• CAS No.: 144690-85-7
• Molecular Formula: C30H36N2O6
• Molecular Weight: 520.626
• Mol file: 144690-85-7.mol

Synonyms:

Chemical Property of 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester

There total 3 articles about 1H-Imidazole-4,5-dicarboxylic acid, 1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-2-propyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester (114772-40-6) + diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate (144689-94-1) → diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate (144690-85-7)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h;

DOI:10.1021/jm950450f

Reference yield:

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate (144690-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / HCl / Ambient temperature

2: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

With hydrogenchloride; potassium tert-butylate;

DOI:10.1021/jm950450f

Reference yield:

2-propylimidazole-4,5-dicarbonitrile (51802-42-7) → diethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-propylimidazole-4,5-dicarboxylate (144690-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / 6N aq. HCl / 8 h / Heating

2: 86 percent / HCl / Ambient temperature

3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

With hydrogenchloride; potassium tert-butylate;

DOI:10.1021/jm950450f

upstream raw materials:

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

2-propyl-1H-imidazole-4,5-dicarboxylic acid

2-propylimidazole-4,5-dicarbonitrile

Downstream raw materials:

ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-hydroxymethyl-2-propylimidazole-5-carboxylate

1-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-hydroxymethyl-2-propyl-1H-imidazole-4-carboxylic acid ethyl ester

1-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester

ethyl 1-<(2'-carboxybiphenyl-4-yl)methyl>-4-methyl-2-propylimidazole-5-carboxylate