51802-42-7

Basic information

• Product Name: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE
• Synonyms: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE;2-PropyliMidazole-4,5-dicarbonitrile;4,5-Dicyano-2-propyl-1H-imidazole;Olmesartan Medoxomil Impurity 4
• CAS NO: 51802-42-7
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Mol File: 51802-42-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 141-143
• Boiling Point: 485.1 °C at 760 mmHg
• Flash Point: 152.5 °C
• Appearance: /
• Density: 1.21
• Vapor Pressure: 1.45E-09mmHg at 25°C
• Refractive Index: 1.543
• PKA: 5.57±0.10(Predicted)
• CAS DataBase Reference: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE(51802-42-7)
• EPA Substance Registry System: 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE(51802-42-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 51802-42-7(Hazardous Substances Data)

Usage

General Description

2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE is a chemical compound with the molecular formula C9H10N4. It is a derivative of imidazole and contains two nitrile groups. 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a ligand in coordination chemistry and as an intermediate in the production of fine chemicals. 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBONITRILE has potential applications in various industrial processes and is of interest to researchers and scientists in the field of organic and medicinal chemistry.

InChI:InChI=1/C8H8N4/c1-2-3-8-11-6(4-9)7(5-10)12-8/h2-3H2,1H3,(H,11,12)

Upstream product

• 43083-12-1 1,1,1-trimethoxybutane 
• 1187-42-4 diaminomaleonitrile 
• 18514-52-8 2,3-diaminomaleonitrile 
• 761441-46-7 N-((Z)-2-amino-1,2-dicyanoethenyl)butyramide 

Downstream Products

• 58954-23-7 2-propyl-1H-imidazole-4,5-dicarboxylic acid 
• 172875-52-4 2-propylimidazole-4-carboxylic acid 
• 157356-73-5 ethyl 4-isopropenyl-2-propylimidazole-5-carboxylate 
• 144690-07-3 ethyl 4-acetyl-2-propylimidazole-5-carboxylate 
• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 
• 144689-93-0 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 
• 172875-53-5 ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate 
• 172876-10-7 ethyl 1-<(2'-carboxybiphenyl-4-yl)methyl>-4-methyl-2-propylimidazole-5-carboxylate 
• 172875-79-5 3-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 172876-11-8 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 154237-82-8 4'-(4,5-Bis-hydroxymethyl-2-propyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester 
• 172875-76-2 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 172875-80-8 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-isopropenyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Preparation method of diacid

The invention relates to a preparation method of diacid, and belongs to the field of medicinal chemistry. The preparation method provided by the invention comprises: carrying out carboxylation reaction on raw materials under the action of acid under a continuous flow reaction condition. The method provided by the invention has the advantages of cheap and easily available raw materials, simple process, low cost, high product purity and yield, green and environment-friendly process, and facilitation of industrialization.

Efficient synthesis of trisimidazole and glutaric acid bearing porphyrins: Ligands for active-site models of bacterial nitric oxide reductase

Ligands (1) for active-site models of bacterial nitric oxide reductase (NOR) have been efficiently synthesized. These compounds (1) feature three imidazolyl moieties and one carboxylic acid residue at the FeB site, which represent the closest available synthetic model ligands of NOR active center. The stereo conformations of these ligands are established on the basis of steric effects and 1H NMR chemical shifts under the ring current effect of the porphyrin.

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.