6-methoxy-2-phenylpyridazin-3(2H)-one

Base Information

• Chemical Name: 6-methoxy-2-phenylpyridazin-3(2H)-one
• CAS No.: 14634-50-5
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• DSSTox Substance ID: DTXSID80424189
• Nikkaji Number: J81.791K
• Wikidata: Q82236653
• Mol file: 14634-50-5.mol

Synonyms:6-methoxy-2-phenylpyridazin-3(2H)-one;14634-50-5;3(2H)-Pyridazinone, 6-methoxy-2-phenyl-;DTXSID80424189;STK976834

Chemical Property of 6-methoxy-2-phenylpyridazin-3(2H)-one

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.074227566
• Heavy Atom Count: 15
• Complexity: 304

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NN(C(=O)C=C1)C2=CC=CC=C2

Technology Process of 6-methoxy-2-phenylpyridazin-3(2H)-one

There total 4 articles about 6-methoxy-2-phenylpyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-hydroxy-2-phenyl-3(2H)-pyridazinone (1698-54-0) + methyl iodide (74-88-4) → 6-methoxy-2-phenyl-2H-pyridazin-3-one (14634-50-5)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃;

Reference yield:

6-hydroxy-2-phenyl-3(2H)-pyridazinone (1698-54-0) → 6-methoxy-2-phenyl-2H-pyridazin-3-one (14634-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

With trichlorophosphate;

DOI:10.1002/hlca.19540370214

Reference yield:

6-chloro-2-phenylpyridazine-3(2H)-one (1698-57-3) + sodium methylate (124-41-4) → 6-methoxy-2-phenyl-2H-pyridazin-3-one (14634-50-5)

Guidance literature:

DOI:10.1002/hlca.19540370214

upstream raw materials:

6-hydroxy-2-phenyl-3(2H)-pyridazinone

methyl iodide

6-chloro-2-phenylpyridazine-3(2H)-one

sodium methylate

Downstream raw materials:

2-methyl-1-phenyl-1,2-dihydro-3,6-pyridazinedione

6-Methoxy-2-phenyl-5-(toluene-4-sulfonylmethyl)-2H-pyridazin-3-one