tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate

Base Information

• Chemical Name: tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate
• CAS No.: 146514-35-4
• Molecular Formula: C9H15NO4
• Molecular Weight: 201.222
• European Community (EC) Number: 625-465-2,855-359-3
• Nikkaji Number: J1.621.380B
• Mol file: 146514-35-4.mol

Synonyms:146514-35-4;tert-Butyl (2-oxotetrahydrofuran-3-yl)carbamate;tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate;132957-40-5;tert-butyl N-(2-oxooxolan-3-yl)carbamate;Boc-DL-homoserine lactone;MFCD04973958;MFCD09037376;(S)-N-Boc-3-aminotetrahydrofuran-2-one;Carbamic acid, (tetrahydro-2-oxo-3-furanyl)-, 1,1-dimethylethyl ester;Boc-Homoser lactone;Boc-D-Homoser lactone;(S)-tert-butyl 2-oxo-tetrahydrofuran-3-ylcarbamate;tert-Butyl(2-oxotetrahydrofuran-3-yl)carbamate;tert-Butyl(tetrahydro-2-oxo-furan-3-yl)-carbamate;SCHEMBL1036703;IMWMFJMYEKHYKG-UHFFFAOYSA-N;STR07680;WFA51435;AKOS016013020;AB89518;AT10140;SY033775;SY113798;CS-0309220;FT-0603908;FT-0603909;METHYL3,5-DICHLORO-4-METHOXYBENZOATE;EN300-169948;tert-Butyl 2-oxo-tetrahydrofuran-3-ylcarbamate;J-006261;2-Oxotetrahydrofuran-3-carbamic acid tert-butyl ester;tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate, 98%;(2-oxo-tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester

Chemical Property of tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 201.10010796
• Heavy Atom Count: 14
• Complexity: 244

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1CCOC1=O

Technology Process of tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate

There total 8 articles about tert-Butyl (tetrahydro-2-oxo-3-furanyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-aminobutyrolactone (1192-20-7) → (RS)-N-tert-butoxycarbonyl-α-amino-γ-butyrolactone (146514-35-4,132957-40-5)

Guidance literature:

With triethylamine; In dichloromethane; for 48h;

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + α-amino-γ-butyrolactone hydrobromide (6305-38-0) → (RS)-N-tert-butoxycarbonyl-α-amino-γ-butyrolactone (146514-35-4,132957-40-5)

Guidance literature:

In dichloromethane; for 96h; Ambient temperature;

DOI:10.1039/P19940000379

Reference yield:

methyl O-benzyl-N-(tert-butoxycarbonyl)-L-homoserinate (254882-48-9) → (RS)-N-tert-butoxycarbonyl-α-amino-γ-butyrolactone (146514-35-4,132957-40-5)

Guidance literature:

palladium on activated carbon; In methanol;

upstream raw materials:

carbon dioxide

N-Boc-2-methyltetrahydro-1,3-oxazine

di-tert-butyl dicarbonate

α-amino-γ-butyrolactone hydrobromide

Downstream raw materials:

2-(tert-butoxycarbonylamino)-4-hydroxy-butanoic acid

N-tert-butyloxycarbonyl-DL-homoserine benzhydryl ester

(S)-2-(tert-butoxycarbonylamino)-1,4-butanediol

(1-(hydroxymethyl)-3-hydroxypropyl)carbamic acid tert-butyl ester