1192-20-7Relevant academic research and scientific papers
Preparation method of alpha-amino-gamma-butyrolactone and salt of alpha-amino-gamma-butyrolactone
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Paragraph 0027-0032, (2020/03/25)
The invention discloses a preparation method of alpha-amino-gamma-butyrolactone and a salt of alpha-amino-gamma-butyrolactone. The preparation method has the advantages of mild reaction, simple operation and high yield, and a byproduct methyl phenyl thioether compound prepared by the preparation method can be recovered to be a corresponding benzyl halide by halogen introduction and other methods,the recovery rate is 72.9%, and the reagent production cost is greatly reduced. The preparation method comprises a following step: reacting methionine with a benzyl halide reagent in an organic solution to obtain the alpha-amino-gamma-butyrolactone and the salt of the alpha-amino-gamma-butyrolactone.
Quorum Sensing Disruption in Vibrio harveyi Bacteria by Clay Materials
Naik, Sajo P.,Scholin, Jonathon,Ching, San,Chi, Fang,Herpfer, Marc
, p. 40 - 44 (2018/01/17)
This work describes the use of clay minerals as catalysts for the degradation of quorum sensing molecule N-(3-oxooctanoyl)-dl-homoserine lactone. Certain clay minerals as a result of their surface properties and porosity can catalytically degrade the quorum sensing molecule into smaller fragments. The disruption of quorum sensing by clay in a growing Gram-negative Vibrio harveyi bacteria culture was also studied by monitoring luminescence and population density of the bacteria, wherein quenching of bacterial quorum sensing activity was observed by means of luminescence reduction. The results of this study show that food-grade clays can be used as biocatalysts in disrupting bacterial activity in various media.
Synthesis method of 2-amino-gamma-butyrolactone hydrochloride
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Paragraph 0025; 0026; 0027, (2017/01/02)
The invention discloses a synthesis method of 2-amino-gamma-butyrolactone hydrochloride (I) for a kind of important chemical, dye, pesticide and medical intermediates. The synthesis method includes the following steps: taking a gamma-butyrolactone compound (II) and a nitroso ester compound (III) as raw materials to react with each other to obtain 2-(hydroxyl imino)-gamma-butyrolactone (IV), and subjecting the compound (IV) to reduction reaction and acidification to obtain the 2-amino-gamma-butyrolactone hydrochloride (I). The method used for preparing the product compound (I) is mild in condition, simple to operate, high in yield, low in environmental pollution, easier for industrial production and the like.
Optical resolution by preferential crystallization of (RS)-α-amino-γ-butyrolactone hydrochloride
Shiraiwa, Tadashi,Miyazaki, Hideya,Ohta, Atsushi,Waki, Yukitaka,Yasuda, Masahiro,Morishita, Toshimitsu,Kurokawa, Hidemoto
, p. 2322 - 2325 (2007/10/03)
(RS)-α-Amino-γ-butyrolactone hydrochloride [(RS)-ABL·HCl] was found to exist as a conglomerate based on the infrared spectrum, solubility, and melting point. Optical resolution by preferential crystallization of (RS)-ABL·HCl was achieved to yield (R)- and (S)-ABL·HCl. The obtained (R)- and (S)-ABL·HCl were recrystallized, taking into account the solubility of (RS)-ABL·HCl to give optically pure (R)- and (S)-ABL·HCl.
