2-Bromo-5-chloro-1,3-dimethylbenzene

Base Information

• Chemical Name: 2-Bromo-5-chloro-1,3-dimethylbenzene
• CAS No.: 14659-58-6
• Molecular Formula: C8H8BrF
• Molecular Weight: 203.054
• Hs Code.: 2903999090
• Mol file: 14659-58-6.mol

Synonyms:2-bromo-5-fluoro-1,3-dimethylbenzene;

Chemical Property of 2-Bromo-5-chloro-1,3-dimethylbenzene

Chemical Property:

• Vapor Pressure: 0.0498mmHg at 25°C
• Boiling Point: 206℃
• Flash Point: 81℃
• PSA: 0.00000
• Density: 1.426
• LogP: 3.20500
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-5-fluoro-m-xylene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Bromo-5-chloro-1,3-dimethylbenzene, also known as 1,3-dimethyl-2-bromo-5-chlorobenzene, has applications primarily in the field of organic chemistry and chemical synthesis. 2-Bromo-5-chloro-1,3-dimethylbenzene serves as a valuable intermediate and building block for the creation of more complex organic molecules. In the pharmaceutical industry, it can be employed in the synthesis of various drug candidates, contributing to the development of potential medications. Additionally, in the field of materials science, it can be used to create specialized polymers and compounds with unique properties. Its multifaceted utility underscores its significance in chemical synthesis and research, where it plays a pivotal role in advancing scientific knowledge and innovation.

Technology Process of 2-Bromo-5-chloro-1,3-dimethylbenzene

There total 9 articles about 2-Bromo-5-chloro-1,3-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3,5-dimethylfluorobenzene (461-97-2) → 2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene (14659-58-6)

Guidance literature:

With bromine; In tetrachloromethane;

DOI:10.1246/bcsj.74.2207

Reference yield: 43.0%

4-bromo-3,5-dimethylbenzylamine (1253927-92-2) → 2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene (14659-58-6)

Guidance literature:

4-bromo-3,5-dimethylbenzylamine; With boron trifluoride diethyl etherate; In toluene; Inert atmosphere;

With tert.-butylnitrite; In toluene; at 110 ℃; for 2.75h; Inert atmosphere;

DOI:10.1021/ja2040392

Reference yield:

2-bromo-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene (1073338-97-2) → 2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene (14659-58-6)

Guidance literature:

With C₁₃H₈BBiF₇NOS; sodium fluoride; 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate; In chloroform-d1; at 90 ℃; for 16h;

DOI:10.1126/science.aaz2258

upstream raw materials:

2,6-dimethyl-4-fluoroaniline

3,5-dimethylfluorobenzene

3,5-dimethyl-4-nitrobenzoic acid

2,6-dimethyl-4-fluoro-1-nitro-benzene

Downstream raw materials:

2,6-Dimethylfluorothiophenol

2,6-dimethyl-4-fluorobenzonitrile

diazobis(4-fluoro-2,6-dimethylphenyl)methane

bis(4-fluoro-2,6-dimethylphenyl)ketimine

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