2,6-Dimethyl-4-fluorophenylboronic acid

Base Information

• Chemical Name: 2,6-Dimethyl-4-fluorophenylboronic acid
• CAS No.: 1392512-54-7
• Molecular Formula: C₈H₁₀BFO₂
• Molecular Weight: 167.976
• Mol file: 1392512-54-7.mol

Synonyms:(4-fluoro-2,6-dimethylphenyl)boronic acid

Chemical Property of 2,6-Dimethyl-4-fluorophenylboronic acid

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,6-Dimethyl-4-fluorophenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-Dimethyl-4-fluorophenylboronic acid

There total 2 articles about 2,6-Dimethyl-4-fluorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Trimethyl borate (121-43-7,63156-11-6) + 2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene (14659-58-6) → (4-fluoro-2,6-dimethylphenyl)boronic acid (1392512-54-7)

Guidance literature:

2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol3019665

Reference yield:

Triisopropyl borate (5419-55-6) + 2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene (14659-58-6) + water (7732-18-5) → (4-fluoro-2,6-dimethylphenyl)boronic acid (1392512-54-7)

Guidance literature:

2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene; With n-butyllithium; at -78 ℃; for 0.5h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere;

water; With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 0.166667h; Inert atmosphere;

Reference yield: 99.0%

1-bromo-2-methoxynaphthalene (3401-47-6) + (4-fluoro-2,6-dimethylphenyl)boronic acid (1392512-54-7) → C19H17FO (1392512-22-9)

Guidance literature:

With Pd-PEPPSI-IPr^An; potassium tert-butylate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol3019665

upstream raw materials:

Trimethyl borate

2‐bromo‐5‐fluoro‐1,3‐dimethylbenzene

Triisopropyl borate

water

Downstream raw materials:

C₁₉H₁₇FO