1,4-Benzenediol, 2-[[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxy-5-(phenyl methoxy)phenyl]methyl]-6-iodo-, 4-benzoate

Base Information

Chemical Name:1,4-Benzenediol, 2-[[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxy-5-(phenyl methoxy)phenyl]methyl]-6-iodo-, 4-benzoate
CAS No.:147067-78-5
Molecular Formula:C45H43IO6Si
Molecular Weight:834.823
Hs Code.:
Mol file:147067-78-5.mol

Synonyms:

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Chemical Property of 1,4-Benzenediol, 2-[[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxy-5-(phenyl methoxy)phenyl]methyl]-6-iodo-, 4-benzoate

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Technology Process of 1,4-Benzenediol, 2-[[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxy-5-(phenyl methoxy)phenyl]methyl]-6-iodo-, 4-benzoate

There total 15 articles about 1,4-Benzenediol, 2-[[3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-methoxy-5-(phenyl methoxy)phenyl]methyl]-6-iodo-, 4-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 147067-77-4
Benzoic acid 3-[5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-benzyl]-4-hydroxy-phenyl ester

: 147067-78-5
Benzoic acid 3-[5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-benzyl]-4-hydroxy-5-iodo-phenyl ester

Guidance literature:: With morpholine; iodine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jo970596h

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 147067-78-5
Benzoic acid 3-[5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-benzyl]-4-hydroxy-5-iodo-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / Et₃N, DMAP / CH₂Cl₂ / 5 h

2: NaH, DMPU / tetrahydrofuran / -10 deg C, 45 min, -10 deg C to rt, 4 h

3: 84 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 0.33 h / -78 - -45 °C

4: 89 percent / Ph₃P, NBS / tetrahydrofuran / 0.25 h / 5 °C

5: 87 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran / 1.) -5 deg C, 4.75 h, 2.) 60 deg C, 17 h

6: 95 percent / pyridinium tosylate / tetrahydrofuran; propan-2-ol / 32 h / 70 °C

7: 75 percent / morpholine, iodine / CH₂Cl₂ / 3 h / Ambient temperature

With morpholine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; pyridinium p-toluenesulfonate; sodium hydride; ethylene dibromide; triethylamine; triphenylphosphine; zinc; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; isopropyl alcohol;
DOI:10.1021/jo970596h

Reference yield:

: 147067-92-3
2-hydroxy-5-benzoyloxybenzaldehyde

: 147067-78-5
Benzoic acid 3-[5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-benzyl]-4-hydroxy-5-iodo-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaH, DMPU / tetrahydrofuran / -10 deg C, 45 min, -10 deg C to rt, 4 h

2: 84 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 0.33 h / -78 - -45 °C

3: 89 percent / Ph₃P, NBS / tetrahydrofuran / 0.25 h / 5 °C

4: 87 percent / 1.) Zn, 1,2-dibromoethane, 2.) (Ph₃P)4Pd / tetrahydrofuran / 1.) -5 deg C, 4.75 h, 2.) 60 deg C, 17 h

5: 95 percent / pyridinium tosylate / tetrahydrofuran; propan-2-ol / 32 h / 70 °C

6: 75 percent / morpholine, iodine / CH₂Cl₂ / 3 h / Ambient temperature

With morpholine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; pyridinium p-toluenesulfonate; sodium hydride; ethylene dibromide; triphenylphosphine; zinc; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; isopropyl alcohol;
DOI:10.1021/jo970596h