147067-92-3Relevant academic research and scientific papers
First elaboration of an olefin metathesis catalytic membrane by grafting a Hoveyda–Grubbs precatalyst on zirconia membranes
Keraani, Adel,Rabiller-Baudry, Murielle,Fischmeister, Cédric,Delaunay, David,Baudry, Amandine,Bruneau, Christian,Renouard, Thierry
, p. 952 - 966 (2017/09/26)
This study is aimed at developing an innovative concept for the preparation of an olefin metathesis catalytic membrane. This goal was achieved by grafting a Grubbs II precatalyst on a zirconia membrane generating a tailor-made Hoveyda–Grubbs precatalyst o
First total chemical synthesis of natural acyl derivatives of some phenolglycosides of the family Salicaceae
Belyanin, Maxim L.,Stepanova, Elena V.,Ogorodnikov, Vladimir D.
, p. 66 - 72 (2013/01/15)
The total synthesis of certain natural phenolglycosides of the family Salicaceae, namely: salireposide, populosides A, B, and C and not occurring in plants desoxysalireposide (2-(β-d-glucopyranosyloxy)-benzylbenzoate) and per-acetate of iso-salireposide (2-(β-d-glucopyranosyloxy)-5-benzoyloxy benzyl alcohol), starting from readily available phenols and glucose was accomplished. A simple method for the synthesis of phenolglycosides derivatives of 2-acyloxy salicyl and gentisyl alcohol was developed. The key step of these natural products' synthesis is a selective removal of acetyl groups in the presence of other acyl groups.
Silica and zirconia supported olefin metathesis pre-catalysts: Synthesis, catalytic activity and multiple-use in dimethyl carbonate
Keraani, Adel,Fischmeister, Cédric,Renouard, Thierry,Le Floch, Marie,Baudry, Amandine,Bruneau, Christian,Rabiller-Baudry, Murielle
, p. 73 - 80 (2012/05/20)
This study is aimed at designing and synthesising new olefin metathesis catalysts grafted onto porous solid supports and using them in dimethyl carbonate (DMC) an eco-friendly solvent. Two hybrid organic-inorganic Hoveyda-type catalysts were prepared in a
Total synthesis of floresolide B and Δ6,7-Z-floresolide B
Nicolaou,Xu, Hao
, p. 600 - 602 (2008/02/10)
The total syntheses of the cytotoxin marine natural product floresolide B (1) and its Δ6,7-Z isomer (2) have been achieved through an olefin metathesis-based strategy. The Royal Society of Chemistry 2006.
Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase
Regan, John
, p. 3408 - 3422 (2007/10/03)
We report the synthesis of a series of diphenylmethane-based oligomers containing anionic and lipophilic functionalities that are potent inhibitors of human leukocyte elastase (HLE). The enzyme inhibition is regulated by the size of the oligomer, as well
Synthesis of functionalized aromatic oligomers from a versatile diphenylmethane template
Bruno,Chang,Choi-Sledeski,Green,McGarry,Volz,Regan
, p. 5174 - 5190 (2007/10/03)
An efficient synthesis of the functionalized diphenylmethane system 1 is described. Selective unmasking of the latent phenol groups on 1 allowed the introduction of various appendages onto the diphenylmethane scaffold via simple alkylation, Mitsunobu etherification, and transition-metal-mediated C- C bond formation. Conversion of 1 teiodide 18 and benzylic zinc reagent 28 followed by palladium(0)-mediated coupling of these derivatives provided homologue 29. Repetitive application of this homologation protocol was used to prepare oligomers of chain length up to 16. Several examples of functional group manipulations on these higher order oligomers are presented. Diphenylmethane 1 was also employed as a key building block in the synthesis of the elastase inhibitor 67. The potential application of extended aromatic oligomers to the field of drug discovery is discussed.
