3-propoxypyridine

Base Information

• Chemical Name: 3-propoxypyridine
• CAS No.: 14773-53-6
• Molecular Formula: C8H11NO
• Molecular Weight: 137.17900
• Mol file: 14773-53-6.mol

Synonyms:3-Propoxy-pyridin;3-Propoxy-pyridine;

Chemical Property of 3-propoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 1.87040

Purity/Quality:

3-propoxy-Pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-propoxypyridine

There total 8 articles about 3-propoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-allyloxy-2-chloropyridine → 3-propoxypyridine (14773-53-6) + 3-(allyloxy)-pyridine (18343-04-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; at 20 ℃; for 2h; under 760.051 Torr; Overall yield = 100 %Spectr.; chemoselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2014.08.008

Reference yield: 65.0%

3-HYDROXYPYRIDINE (109-00-2) + propyl bromide (106-94-5) → 3-propoxypyridine (14773-53-6)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

3-HYDROXYPYRIDINE; propyl bromide; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(99)00263-X

Reference yield: 60.0%

3-allyloxy-2-chloropyridine (86382-38-9) → 3-propoxypyridine (14773-53-6) + 3-(allyloxy)-pyridine (18343-04-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; at 20 ℃; for 2h; under 760.051 Torr; Overall yield = 100 %Spectr.; chemoselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2014.08.008

upstream raw materials:

3-HYDROXYPYRIDINE

propyl bromide

1-iodo-propane

3-allyloxy-2-chloropyridine

Refernces

• 1、 Kinarivala, Nihar,Trippier, Paul C.. "Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines". supporting information. p. 5386 - 5389. Retrieved 2015/01/16.
• 2、 Penkett,Simpson. "New methods of preparing cyclopentenone ketals: The photosolvolysis of 3-alkoxypyridinium tetrafluoroborates". . p. 93 - 95. Retrieved 2007/10/03.