4-(3-methoxyphenyl)sulfanylbenzonitrile

Base Information

• Chemical Name: 4-(3-methoxyphenyl)sulfanylbenzonitrile
• CAS No.: 148901-64-8
• Molecular Formula: C14H11NOS
• Mol file: 148901-64-8.mol

Synonyms:

Chemical Property of 4-(3-methoxyphenyl)sulfanylbenzonitrile

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-methoxyphenyl)sulfanylbenzonitrile

There total 5 articles about 4-(3-methoxyphenyl)sulfanylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-methoxybenzenethiol (15570-12-4) + 4-fluorobenzonitrile (1194-02-1,143234-87-1) → 3-methoxylphenyl(4-cyanophenyl)sulfane (148901-64-8)

Guidance literature:

With potassium fluoride on basic alumina; 18-crown-6 ether; In acetonitrile; for 18h; Heating;

DOI:10.1021/jo00064a004

Reference yield: 87.0%

4-Cyanochlorobenzene (623-03-0) + 3-methoxybenzenethiol (15570-12-4) → 3-methoxylphenyl(4-cyanophenyl)sulfane (148901-64-8)

Guidance literature:

With fac-tris[2-phenylpyridinato-C²,N]iridium(III); caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201610414

Reference yield: 55.0%

sodium S-(3-methoxyphenyl) thiosulfate (1561023-51-5) + 4-cyanophenyldiazonium tetrafluoroborate (2252-32-6) → 3-methoxylphenyl(4-cyanophenyl)sulfane (148901-64-8)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; potassium carbonate; In water; dimethyl sulfoxide; at 20 ℃; for 5h; Irradiation; Inert atmosphere;

upstream raw materials:

3-methoxybenzenethiol

4-fluorobenzonitrile

sodium S-(3-methoxyphenyl) thiosulfate

4-Aminobenzonitrile

Refernces

• 1、 Jiang, Min,Li, Haifang,Yang, Haijun,Fu, Hua. "Room-Temperature Arylation of Thiols: Breakthrough with Aryl Chlorides". supporting information. p. 874 - 879. Retrieved 2017/01/14.
• 2、 Li, Yiming,Xie, Weisi,Jiang, Xuefeng. "Mechanistic Study of a Photocatalyzed C-S Bond Formation Involving Alkyl/Aryl Thiosulfate". supporting information. p. 16059 - 16065. Retrieved 2015/11/03.