Methyl 1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate
• CAS No.: 149505-71-5
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.293
• Hs Code.: 2933790090
• Mol file: 149505-71-5.mol

Synonyms:methyl 1-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxylate;1-(4-methoxy-benzyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester;1-(4-METHOXYBENZYL)-4-NITRO-1H-IMIDAZOLE;1-p-methoxybenzyl-4-nitroimidazole;

Chemical Property of Methyl 1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate

Chemical Property:

• Boiling Point: 433.8±45.0 °C(Predicted)
• PKA: -1.94±0.40(Predicted)
• PSA: 55.84000
• Density: 1.217±0.06 g/cm3(Predicted)
• LogP: 1.15460

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate

There total 4 articles about Methyl 1-(4-Methoxybenzyl)-5-oxopyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Dimethyl itakonate (617-52-7) + 4-methoxy-benzylamine (2393-23-9) → methyl 1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylate (149505-71-5)

Guidance literature:

In methanol; at 20 ℃; for 2h; Reflux;

DOI:10.1016/j.bmcl.2011.10.122

Reference yield: 28.0%

5-oxopyrrolidine-3-carboxylic acid methyl ester (35309-35-4,428518-31-4) + p-methoxybenzyl chloride (824-94-2) → methyl 1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylate (149505-71-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

4-methoxy-benzylamine (2393-23-9) → methyl 1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylate (149505-71-5)

Guidance literature:

With hydrogenchloride; In methanol;

upstream raw materials:

Dimethyl itakonate

4-methoxy-benzylamine

5-oxopyrrolidine-3-carboxylic acid methyl ester

p-methoxybenzyl chloride

Downstream raw materials:

4-Hydroxymethyl-1-(4-methoxy-benzyl)-pyrrolidine-2-one

N-methoxy-1-(4-methoxybenzyl)-N-methyl-5-oxopyrrolidine-3-carboxamide

1-(4-methoxybenzyl)-4-(phenoxymethyl)pyrrolidin-2-one

4-(phenoxymethyl)pyrrolidin-2-one

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