D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester,trifluoromethanesulfonate (ester)

Base Information

• Chemical Name: D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester,trifluoromethanesulfonate (ester)
• CAS No.: 149709-56-8
• Molecular Formula: C16H20F3NO7S
• Molecular Weight: 427.399
• Mol file: 149709-56-8.mol

Synonyms:D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(trifluoromethyl)sulfonyl]-, methyl ester;methyl(R)-2-(t-butoxycarbonylamino)-3-[4-(trifluoromethylsulfonyloxy)phenyl]-propionate;N-t-Butoxycarbonyl-4-trifluoro methanesulfonyloxy-D-phenylalanine methyl ester;Methyl (R)-2-TERT-BUTOXYCARBONYLAMINO-3- (4-TRI- FLUOROMETHANESULPHONYLOXYPHENYL) propionate;

Chemical Property of D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester,trifluoromethanesulfonate (ester)

Chemical Property:

• PSA: 116.38000
• LogP: 3.99550

Purity/Quality:

99% ^*data from raw suppliers

methylN-[(1,1-dimethylethoxy)carbonyl]-O-[(trifluoromethyl)sulfonyl]-D-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester,trifluoromethanesulfonate (ester)

There total 5 articles about D-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester,trifluoromethanesulfonate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

trifluoromethylsulfonic anhydride (358-23-6) + N-(tert-butoxycarbonyl)-D-tyrosine methyl ester (76757-90-9) → methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-D-tyrosinate (149709-56-8)

Guidance literature:

With pyridine; In dichloromethane; at -15 ℃; for 0.0833333h;

DOI:10.1021/jm00010a014

Reference yield: 91.0%

→ methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-D-tyrosinate (149709-56-8)

Guidance literature:

Reference yield:

α-t-BOC-(R)-tyrosine methyl ester → methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-D-tyrosinate (149709-56-8)

Guidance literature:

With pyridine; trifluoromethanesulfonic acid anhydride; In dichloromethane;

upstream raw materials:

trifluoromethylsulfonic anhydride

N-(tert-butoxycarbonyl)-D-tyrosine methyl ester

L-tyrosine

D-tyrosine methylester hydrochloride

Downstream raw materials:

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt

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