5-Methoxynaphthalen-2-ol

Base Information

• Chemical Name: 5-Methoxynaphthalen-2-ol
• CAS No.: 150712-57-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.199
• DSSTox Substance ID: DTXSID60566273
• Nikkaji Number: J2.682.594F
• Wikidata: Q82451821
• Mol file: 150712-57-5.mol

Synonyms:5-Methoxynaphthalen-2-ol;1-Methoxy-6-naphthol;150712-57-5;6-Hydroxy-2-methoxynaphthalene;SCHEMBL3163561;2-hydroxy-5-methoxy naphthalene;5-methoxy-2-hydroxy naphthalene;DTXSID60566273;HKLUQGYAKFXFEO-UHFFFAOYSA-N

Chemical Property of 5-Methoxynaphthalen-2-ol

Chemical Property:

• Melting Point: 62 °C
• Boiling Point: 185-186 °C(Press: 8 Torr)
• PKA: 9.43±0.40(Predicted)
• PSA: 29.46000
• Density: 1.193±0.06 g/cm3(Predicted)
• LogP: 2.55400
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

1-Methoxy-6-naphthol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C=CC(=C2)O

Technology Process of 5-Methoxynaphthalen-2-ol

There total 9 articles about 5-Methoxynaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methoxynaphthalen-2-yl acetate → 5-methoxynaphthalen-2-ol (150712-57-5)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2015.06.045

Reference yield: 27.0%

1,6-dimethoxynaphthalene (3900-49-0) → 5-methoxynaphthalen-2-ol (150712-57-5)

Guidance literature:

With bromocatecholborane; In 1,2-dichloro-ethane; for 72h; Heating / reflux;

Reference yield: 24.0%

((5-methoxy-3,4-dihydronaphthalen-2-yl)oxy)trimethylsilane → 5-methoxynaphthalen-2-ol (150712-57-5)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); 2-bromo-2-nitropropane; In acetonitrile; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1039/d1cc06529g

upstream raw materials:

1,6-dihydroxynaphthalene

methanol

1,6-dimethoxynaphthalene

6-Hydroxy-1-tetralone

Downstream raw materials:

2-[4-[[2-(5-methoxy-2-naphthyl)-5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]amino]phenyl]acetic acid

C₂₈H₂₇N₃O₅S

4-hydroxydibenzacridine