3900-49-0Relevant articles and documents
A simple and efficient process for the preparation of 1,6- dimethoxynaphthalene
Zhang, Tianyong,Yang, Qiusheng,Shi, Huixian,Chi, Lifeng
, p. 647 - 651 (2009)
1,6-Dimethoxynaphthalene (1,6-DMN) was prepared by the O-dimethylation of 1,6-dihydroxynaphthalene (1,6-DHN) with dimethyl sulfate (DMS) in the presence of sodium hydroxide and additives in different solvents. The main reaction determining factors were divided into three categories with respect to yield and purity of 1,6-DMN: (1) Type of solvents and adding methods of NaOH had the highest effect on the results. (2) Amount of DMS and concentration of NaOH were less important. (3) Reaction time and temperature were the least important factors. The best reductant was Na2S2O4, and it was only under N2 atmosphere that yield and purity were also good. The improved process provides more than 99% yield, which considerably reduces the cost of 1,6-DMN, and more than 98% purity eliminates the purification process in the follow-up industrial production.
QUENCHER
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Paragraph 0643, (2018/01/04)
A quencher is disclosed having a compound represented by the following general formula (1): wherein R5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y1 represents an oxygen atom, or the like; An? represents an anion; Ar1 represents a specific ring structure; * and ** represent binding positions; Ar2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R5, Y1, Ar1, Ar2, n1, * and ** are the same as described above.).
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen- 2-one as a new class of microtubule-targeting agents
Liu, Jia,Zheng, Can-Hui,Ren, Xiao-Hui,Zhou, Feng,Li, Wei,Zhu, Ju,Lv, Jia-Guo,Zhou, You-Jun
scheme or table, p. 5720 - 5733 (2012/07/30)
A series of 1-benzylidene-3,4-dihydronaphthalen-2-one derivatives were designed and synthesized, and their biological activities in vitro and in vivo were evaluated. The results showed a number of the title compounds exhibiting potent nanomolar activity in several human cancer cell lines. Of these, compound 22b showed the strongest inhibitory activity against human CEM, MDA-MBA-435, and K562 cells (IC50 = 1 nM), displayed in vitro inhibition of tubulin polymerization (IC50 = 3.93 μM), and significantly induced cell cycle arrest in G2/M phase. In addition, compound 22b could inhibit the tumor growth in colon nude mouse xenograft tumor model significantly and seemed safer than CA-4 when achieving a similar tumor suppression. This study provided a new molecular scaffold for the further development of antitumor agents that target tubulin.