N-ethyl-2,4,6-trimethylbenzenesulfonamide

Base Information

• Chemical Name: N-ethyl-2,4,6-trimethylbenzenesulfonamide
• CAS No.: 151915-07-0
• Molecular Formula: C11H17NO2S
• Molecular Weight: 227.327
• DSSTox Substance ID: DTXSID60355402
• Wikidata: Q82134281
• Mol file: 151915-07-0.mol

Synonyms:N-ethyl-2,4,6-trimethylbenzenesulfonamide;151915-07-0;N-ethyl-2,4,6-trimethylbenzene-1-sulfonamide;SCHEMBL3867855;DTXSID60355402;STK083352;AKOS000671469;SB80373;CS-0447001;EN300-1452575;AP-263/11633956;SR-01000318871;SR-01000318871-1;Z45528345

Chemical Property of N-ethyl-2,4,6-trimethylbenzenesulfonamide

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 227.09799996
• Heavy Atom Count: 15
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNS(=O)(=O)C1=C(C=C(C=C1C)C)C

Technology Process of N-ethyl-2,4,6-trimethylbenzenesulfonamide

There total 2 articles about N-ethyl-2,4,6-trimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-mesitylenesulphonyl chloride (773-64-8) + ethanamine hydrochloride (557-66-4) → N-ethyl-(2-mesitylene)sulfonamide (151915-07-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/jm00072a020

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) + ethylamine (75-04-7,85404-22-4) → N-ethyl-(2-mesitylene)sulfonamide (151915-07-0)

Guidance literature:

With potassium hydroxide;

Reference yield: 95.0%

trans-1-cyano-2-(mesitylenesulfonyloxymethyl)-cyclopropane + N-ethyl-(2-mesitylene)sulfonamide (151915-07-0) → N-(1-cyanocyclopropylmethyl)-N-ethyl-mesitylenesulfonamide

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 5 ℃; for 11h;

upstream raw materials:

2-mesitylenesulphonyl chloride

ethylamine

ethanamine hydrochloride

Downstream raw materials:

N-ethyl-N-(3-iodopropyl)-(2-mesitylene)sulfonamide

N-(3-bromo-propyl)-N-ethyl-2,4,6-trimethyl-benzenesulfonamide

N-(4-bromobutyl)-N-ethylmesitylenesulfonamide

N-(5-bromopentyl)-N-ethylmesitylenesulfonamide