Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (S)-

Base Information

Chemical Name:Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (S)-
CAS No.:151929-52-1
Molecular Formula:C18H27NO4
Molecular Weight:321.417
Hs Code.:
Mol file:151929-52-1.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (S)-

There total 1 articles about Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl](phenylmethyl)amino]-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 151929-50-9
ethyl (2E,4S)-4-[benzyl(tert-butoxycarbonyl)amino]pent-2-enoate

: 151929-52-1
methyl 4(S)-[N-benzyl-N-(tert-butyloxycarbonyl)]aminopentanoate

Guidance literature:: With magnesium;
DOI:10.1016/0040-4039(93)88053-L

Reference yield: 80.0%

: 151929-52-1
methyl 4(S)-[N-benzyl-N-(tert-butyloxycarbonyl)]aminopentanoate

: 477952-66-2
4(S)-[N-benzyl-N-(tert-butyloxycarbonyl)]aminopentanal

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 0.75h;
DOI:10.1021/ja051657t

Reference yield:

: 151929-52-1
methyl 4(S)-[N-benzyl-N-(tert-butyloxycarbonyl)]aminopentanoate

: 477952-54-8
(3S,6S)-N-benzyl-2-methyl-2-nitro-3-(diphenylphosphatoxy)-6-heptylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DIBAL-H / hexane; toluene / 0.75 h / -78 °C

2: potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol / 24 h / 0 - 20 °C

3: DMAP / CH₂Cl₂ / 20 °C

4: TMSOTf; 2,6-lutidine / CH₂Cl₂ / 0.5 h / 20 °C

With 2,6-dimethylpyridine; dmap; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; diisobutylaluminium hydride; In hexane; dichloromethane; toluene; acetonitrile; tert-butyl alcohol; 2: Henry reaction;
DOI:10.1021/ja051657t