Technology Process of 3-Cyclohexen-1-one, 3-(hydroxymethyl)-2,2,4-trimethyl-
There total 13 articles about 3-Cyclohexen-1-one, 3-(hydroxymethyl)-2,2,4-trimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 88 percent / (+/-)-camphor-10-sulfonic acid / benzene / 0.5 h / Heating
2.1: LiHMDS / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 89 percent / hexane; tetrahydrofuran / 3.5 h / -78 - 20 °C
3.1: hydrazine hydrate; triethylamine / ethanol / 312 h / Heating
4.1: 9.2 g / DBN; I2 / diethyl ether / 0.5 h / 20 °C
5.1: t-BuLi / pentane; tetrahydrofuran / 0.5 h / -78 °C
5.2: pentane; tetrahydrofuran / 1.67 h / -78 - 20 °C
6.1: CeCl3*7H2O; NaBH4 / methanol / 0.5 h / 0 °C
7.1: 2.75 g / HCl / H2O / 0.5 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; 2,6-dichloro-benzonitrile; camphor-10-sulfonic acid; iodine; tert.-butyl lithium; hydrazine hydrate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; pentane; benzene;
6.1: Luche reduction;
DOI:10.1016/S0040-4020(03)00699-9
- Guidance literature:
-
With
potassium hydroxide;
In
tert-butyl alcohol;
at 70 ℃;
for 4h;
Yield given;
DOI:10.1039/c39920001117
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / 72 h / 130 °C
2: 90 percent Turnov. / KOH / 2-methyl-propan-2-ol / 4 h / 70 °C
With
potassium hydroxide;
In
tert-butyl alcohol;
DOI:10.1021/ja00107a007
