N-ethyl-2-methoxyaniline

Base Information

• Chemical Name: N-ethyl-2-methoxyaniline
• CAS No.: 15258-43-2
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• European Community (EC) Number: 828-420-7
• DSSTox Substance ID: DTXSID50447128
• Nikkaji Number: J1.362.819J
• Mol file: 15258-43-2.mol

Synonyms:N-ethyl-2-methoxyaniline;15258-43-2;Benzenamine, N-ethyl-2-methoxy-;N-Ethyl-2-methoxy-benzenamine;2-methoxyphenyl-ethylamine;n-ethyl-2-methoxybenzenamine;SCHEMBL1022424;DTXSID50447128;RUSPWDWPGXKTFO-UHFFFAOYSA-N;STL068917;AKOS000231389;CS-0447019;EN300-32664;F78857

Chemical Property of N-ethyl-2-methoxyaniline

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC1=CC=CC=C1OC

Technology Process of N-ethyl-2-methoxyaniline

There total 20 articles about N-ethyl-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methoxy-phenylamine (90-04-0) + acetonitrile (75-05-8,26809-02-9) → N-ethyl-2-methoxyaniline (15258-43-2)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In water; at 20 ℃; for 2.2h;

DOI:10.1021/ol047580f

Reference yield: 96.0%

2-Nitroanisole (91-23-6) + acetonitrile (75-05-8,26809-02-9) → N-ethyl-2-methoxyaniline (15258-43-2)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In water; at 20 ℃; for 2.5h;

DOI:10.1021/ol047580f

Reference yield: 94.0%

N-ethyl-2-methoxy-N-nitrosobenzenamine → N-ethyl-2-methoxyaniline (15258-43-2)

Guidance literature:

With triethylsilane; iodine; In dichloromethane; at 20 ℃; for 0.25h;

DOI:10.1002/adsc.201701047

upstream raw materials:

N-(2-methoxy-phenyl)-diacetamide

ethanol

2-methoxy-phenylamine

methanol

Downstream raw materials:

trans-crotonic acid-(N-ethyl-o-anisidide)

N-ethyl-N-(2-methoxy-phenyl)-thiourea

2-ethylaminophenol

N-ethyl-N-(2-methoxyphenyl)propionamide