2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO2H-CHROMENE-3-CARBONITRILE

Base Information

• Chemical Name: 2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO2H-CHROMENE-3-CARBONITRILE
• CAS No.: 153790-54-6
• Molecular Formula: C16H16N2O2S
• Molecular Weight: 300.37500
• Mol file: 153790-54-6.mol

Synonyms:2-Amino-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4-(2-thienyl)-4H-benzopyran-3-carbonitril;2-amino-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4-(thiophene-2-yl)-4H-chromene-3-carbonitrile;2-amino-5,6,7,8-tetrahydro-4-(thiophen-2-yl)-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile;2-amino-7,7-dimethyl-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4H-benzopyran-3-carbonitrile;2-amino-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4-(thiophen-2-yl)-4H-chromene-3-carbonitrile;2-amino-5,6,7,8-tetrahydro-7,7-dimethyl-4-(thiophen-2-yl)-5-oxo-4H-chromene-3-carbonitrile;2-Amino-7,7-dimethyl-5-oxo-4-thiophen-2-yl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;

Chemical Property of 2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO2H-CHROMENE-3-CARBONITRILE

Chemical Property:

• PSA: 104.35000
• LogP: 3.89928

Purity/Quality:

99.90% ^*data from raw suppliers

2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO-2H-CHROMENE-3-CARBONITRILE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO2H-CHROMENE-3-CARBONITRILE

There total 3 articles about 2-AMINO-7,7-DIMETHYL-5-OXO-4-(2-THIENYL)-4,6,7,8-TETRAHYDRO2H-CHROMENE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiophene-2-carbaldehyde (98-03-3) + dimedone (126-81-8) + malononitrile (109-77-3) → 2-amino-7,7-dimethyl-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (153790-54-6)

Guidance literature:

With potassium phtalimide; at 20 ℃; for 0.1h; Milling;

DOI:10.1039/c4gc00411f

Reference yield: 91.0%

2-(2-thienyl)-1-cyanoacrylonitrile (28162-32-5) + dimedone (126-81-8) → 2-amino-7,7-dimethyl-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (153790-54-6)

Guidance literature:

In water; for 0.05h; microwave irradiation;

DOI:10.1080/00397910701572696

Reference yield:

thiophene-2-carbaldehyde (98-03-3) → 2-amino-7,7-dimethyl-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (153790-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / sodium ethoxide / ethanol

2: 76 percent / morpholine / ethanol / Heating

With morpholine; sodium ethanolate; In ethanol;

DOI:10.1002/ardp.200400881

upstream raw materials:

thiophene-2-carbaldehyde

dimedone

malononitrile

2-(2-thienyl)-1-cyanoacrylonitrile

Downstream raw materials:

2-Triphenylphosphoranylidenamino-4H-benzopyrano<3,2-e><1,2,4>triazolo<1,5-c>pyrimidin-11-on