28162-32-5

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 14, p. 790, 1949 DOI: 10.1021/jo01157a011

InChI:InChI=1/C8H4N2S/c9-5-7(6-10)4-8-2-1-3-11-8/h1-4H

Upstream product

• 39145-35-2 2-cyano-3-thiophen-2-yl-thioacrylamide 
• 18440-58-9 1-(N-phenylhydrazono)-1-chloropropanone 
• 75482-50-7 2-(2-phenylhydrazono)-2-chloro-1-phenylethanone 
• 98-03-3 thiophene-2-carbaldehyde 
• 112-54-9 Dodecanal 
• 109-77-3 malononitrile 

Downstream Products

• 125610-77-7 1-cyano-2-(1-thiophenyl)-benzene 
• 79492-48-1 2-amino-3-cyano-4,6-di-(2'-thienyl)-pyridine 
• 84071-21-6 4-thenylidene-2-thioxoimidazolidin-5-one 
• 18015-04-8 5-<2-thienylmethylene>-2,4,6 (1H,3H,5H)pyrimidinetrione 
• 120244-32-8 5-(2-thienylmethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione 
• 112906-28-2 2-amino-4,6-di(thiophen-2-yl)isophthalonitrile 
• 115802-03-4 2-amino-4-(furan-2-yl)-6-(thiophen-2-yl)isophthalonitrile 
• 134305-32-1 3-amino-4-cyano-5-(3-thienyl)benzocoumarin 
• 127118-65-4 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile 
• 95644-02-3 4,6-Diamino-5-[1-thiophen-2-yl-meth-(E)-ylidene]-2-thioxo-2,5-dihydro-pyridine-3-carbonitrile 
• 77198-56-2 3-amino-5-(thiophen-2-yl)-[1,1'-biphenyl]-2,4-dicarbonitrile 
• 129014-26-2 5-Amino-6-cyano-3-oxo-7-thiophen-2-yl-2-[1-thiophen-2-yl-meth-(E)-ylidene]-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxylic acid (2-ethyl-phenyl)-amide 
• 129340-06-3 1-Thiophen-2-yl-3-thioxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile 
• 87736-60-5 2-amino-6-phenyl-4-(2-thienyl)-4H-pyran-3,5-dicarbonitrile 

Relevant academic research and scientific papers

One-step method for the synthesis of aryl olefins from aryl aldehydes and aliphatic aldehydes

A conceptually new one-step reaction affording unexpected aryl olefinic product from aromatic aldehyde, aliphatic aldehyde and malononitrile in the presence of acetic acid-ammonium acetate under mild reaction conditions without using any metal catalyst is reported. This novel reaction was used to prepare a number of substituted aryl olefins including new molecules.

Reactions with hydrazonoyl halides XIX1: Synthesis of some pyrazole and 5-arylazothiazole derivatives

Hydrazonoyl chlorides 1 reacted with 2-aryl-1-cyano-1-thiazol-2-ylethenes 2 in presence of triethylamine to give the cycloadducts 4. which were converted to the corresponding pyrazoles 5 by the action of sodium methoxide. The reaction of hydrazonoyl halides 1 and 6 with each of 2-arylidene-2-cyanoethanethioamides 7 and 2-arylhydrazono-2-cyanoethanethioamides 14 in ethanolic triethylamine or ethanolic sodium hydroxide solutions, has been investigated. Structures of all the products were established on the basis of their spectral data and alternative synthesis.