Carbamic acid, [(hydroxymethylphosphinyl)methyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(hydroxymethylphosphinyl)methyl]-, phenylmethyl ester
• CAS No.: 154370-37-3
• Molecular Formula: C10H14NO4P
• Molecular Weight: 243.199
• Mol file: 154370-37-3.mol

Synonyms:

Chemical Property of Carbamic acid, [(hydroxymethylphosphinyl)methyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(hydroxymethylphosphinyl)methyl]-, phenylmethyl ester

There total 4 articles about Carbamic acid, [(hydroxymethylphosphinyl)methyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(aminomethyl)(methyl)phosphinic acid (15901-11-8) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid (154370-37-3)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; Ambient temperature;

DOI:10.1016/S0040-4020(01)80258-1

Reference yield: 87.0%

methyl N-benzyloxycarbonylaminomethyl(P-methyl)phosphinate → N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid (154370-37-3)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 48h;

DOI:10.1021/jm800570q

Reference yield: 67.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + O-benzyl carbamate (621-84-1) + Adamantan-1-ylamine; compound with methyl-phosphinic acid → N-benzyloxycarbonylaminomethyl(P-methyl)phosphinic acid (154370-37-3)

Guidance literature:

With acetyl chloride; 0 deg C -> r.t.;

DOI:10.1016/0040-4039(96)00839-8

upstream raw materials:

(aminomethyl)(methyl)phosphinic acid

benzyl chloroformate

formaldehyd

O-benzyl carbamate

Refernces

• 1、 Vassiliou, Stamatia,Grabowiecka, Agnieszka,Kosikowska, Paulina,Yiotakis, Athanasios,Kafarski, Pawe?,Berlicki, Lukasz. "Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases". experimental part. p. 5736 - 5744. Retrieved 2009/08/16.
• 2、 Chen, Shoujun,Lin, Chun-Hung,Walsh, Christopher T.,Coward, James K.. "Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase". . p. 505 - 510. Retrieved 2007/10/03.