4-(2-Fluoroethoxy)aniline

Base Information

• Chemical Name: 4-(2-Fluoroethoxy)aniline
• CAS No.: 1547-12-2
• Molecular Formula: C8H10FNO
• Molecular Weight: 155.172
• European Community (EC) Number: 832-866-8
• DSSTox Substance ID: DTXSID60567669
• Wikidata: Q82453639
• Mol file: 1547-12-2.mol

Synonyms:4-(2-Fluoroethoxy)aniline;1547-12-2;Benzenamine, 4-(2-fluoroethoxy)-;SCHEMBL12275026;DTXSID60567669;BAA54712;AKOS017529817;CS-0227021;EN300-762584;G33755;A1-05090;F1967-9263;Z1262631146

Chemical Property of 4-(2-Fluoroethoxy)aniline

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 155.074642105
• Heavy Atom Count: 11
• Complexity: 102

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)OCCF

Technology Process of 4-(2-Fluoroethoxy)aniline

There total 8 articles about 4-(2-Fluoroethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

tert-butyl (4-(2-fluoroethoxy)phenyl)carbamate (1609428-90-1) → 4-(2-fluoro-ethoxy)-aniline (1547-12-2)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; Inert atmosphere;

DOI:10.1021/jm5001453

Reference yield: 97.0%

1-(2-fluoroethoxy)-4-nitrobenzene → 4-(2-fluoro-ethoxy)-aniline (1547-12-2)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; water; at 20 ℃;

Reference yield: 87.0%

→ 4-(2-fluoro-ethoxy)-aniline (1547-12-2)

Guidance literature:

upstream raw materials:

4-acetamidophenyl 2-fluoroethyl ether

4-acetaminophenol

4-nitro-phenol

4-N-tert-butoxycarbonylaminophenol

Downstream raw materials:

4-(2-fluoro-ethoxy)-phenylisocyanate

ethyl 1-(4-(2-fluoroethoxy)phenyl)-1H-1,2,3-triazole-4-carboxylate

1-(4-(2-fluoroethoxy)phenyl)-1H-1,2,3-triazole-4-carboxylic acid

N-(4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl)-1-(4-(2-fluoroethoxy)phenyl)-1H-1,2,3-triazole-4-carboxamide