[2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester

Base Information

• Chemical Name: [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester
• CAS No.: 915287-82-0
• Molecular Formula: C₁₆H₂₄FN₃O₄
• Molecular Weight: 341.383
• Mol file: 915287-82-0.mol

Synonyms:[2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester

Chemical Property of [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester

There total 9 articles about [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(2-fluoro-ethoxy)-phenylisocyanate (915287-80-8) + N-BOC-1,2-diaminoethane (57260-73-8) → [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester (915287-82-0)

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1002/jlcr.1037

Reference yield: 67.0%

2-fluoroethanol (371-62-0) + tert-butyl 2-(3-(4-hydroxyphenyl)ureido)ethylcarbamate (1323276-66-9) → [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester (915287-82-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 2-(3-(4-(benzyloxy)phenyl)ureido)ethylcarbamate → [2-[3-(4-(2-fluoro-ethoxy)-phenyl)-ureido]-ethyl]-carbamic acid t-butyl ester (915287-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 12 h / 2585.81 Torr

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol;

DOI:10.1021/ml1002458

upstream raw materials:

4-(2-fluoro-ethoxy)-phenylisocyanate

N-BOC-1,2-diaminoethane

4-acetaminophenol

4-(2-fluoro-ethoxy)-aniline