1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid

Base Information

Chemical Name:1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid
CAS No.:155302-06-0
Molecular Formula:C13H23NO4
Molecular Weight:257.33
Hs Code.:
European Community (EC) Number:843-063-7
Mol file:155302-06-0.mol

Synonyms:1-(tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid;155302-06-0;4,4-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylic Acid;SCHEMBL9003564;MYPAWYSOGSZUNS-UHFFFAOYSA-N;MFCD24473744;AKOS037648756;BS-15490;CS-0447316;FT-0762406;W18229;EN300-1071348;1-tert-butyloxycarbonyl-4,4-dimethylpipecolic acid;Z1508744462;1-(t-Butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid;1-(tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylicacid;1-[(tert-butoxy)carbonyl]-4,4-dimethylpiperidine-2-carboxylic acid

Suppliers and Price of 1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:257.16270821
Heavy Atom Count:18
Complexity:343

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCN(C(C1)C(=O)O)C(=O)OC(C)(C)C)C

Technology Process of 1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid

There total 2 articles about 1-(Tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 137734-86-2
4,4-dimethyl-pipecolic acid

: 155302-06-0
(±)-1-tert-butoxycarbonyl-4,4-dimethylpiperidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 23h; Ambient temperature;
DOI:10.1021/jm9608523

Reference yield: 22.0%

: benzyl (R)-6-tert-butoxycarbonyl-6-azaspiro[2.5]octane-5-carboxylate

: 155302-06-0
(±)-1-tert-butoxycarbonyl-4,4-dimethylpiperidine-2-carboxylic acid

Guidance literature:: benzyl (R)-6-tert-butoxycarbonyl-6-azaspiro[2.5]octane-5-carboxylate; With 5%-palladium/activated carbon; hydrogen; acetic acid; at 20 ℃; for 1h;

With platinum(IV) oxide; hydrogen; acetic acid; at 100 ℃;

With di-tert-butyl dicarbonate; sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

: 1014645-87-4
methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

: 155302-06-0
(±)-1-tert-butoxycarbonyl-4,4-dimethylpiperidine-2-carboxylic acid

: 1417743-57-7
tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-4,4-dimethylpiperidine-1-carboxylate

Guidance literature:: (±)-1-tert-butoxycarbonyl-4,4-dimethylpiperidine-2-carboxylic acid; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

methyl 4-(1-aminocyclopropyl)benzoate hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;