4-(Hydroxymethyl)oxazolidin-2-one

Base Information

• Chemical Name: 4-(Hydroxymethyl)oxazolidin-2-one
• CAS No.: 15546-08-4
• Molecular Formula: C4H7NO3
• Molecular Weight: 117.104
• European Community (EC) Number: 828-539-4
• Nikkaji Number: J1.730.764I
• Mol file: 15546-08-4.mol

Synonyms:4-(hydroxymethyl)oxazolidin-2-one;15546-08-4;4-(hydroxymethyl)-1,3-oxazolidin-2-one;2-Oxazolidinone, 4-(hydroxymethyl)-;MFCD11045779;MFCD11847629;(R)-4-(Hydroxymethyl)-2-oxazolidinone;4-methyloloxazolidin-2-one;SCHEMBL1775806;MEXGFDVEUOGVFI-UHFFFAOYSA-N;2-oxo-1,3-oxazolidin-4-methanol;4-(hydroxymethyl) oxazolidin-2-one;4-(hydroxymethyl)-oxazolidin-2-one;AC1845;MFCD11847630;AKOS006307608;4-Hydroxymethyl-1,3-oxazolidin-2-one;SB44875;SB44931;CS-12132;SY038213;SY251331;SY284529;CS-0309754;EN300-122168;F2147-2878

Chemical Property of 4-(Hydroxymethyl)oxazolidin-2-one

Chemical Property:

• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 117.042593085
• Heavy Atom Count: 8
• Complexity: 104

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC(=O)O1)CO

Technology Process of 4-(Hydroxymethyl)oxazolidin-2-one

There total 5 articles about 4-(Hydroxymethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + urea (57-13-6) → 4-hydroxymethyl-1,3-dioxolan-2-one (931-40-8) + 4-Hydroxymethyl oxazolidin-2-one (15546-08-4)

Guidance literature:

With boiler ash; at 110 ℃; for 4h; Reagent/catalyst; Temperature; Time; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c4ra02910k

Reference yield: 57.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + urea (57-13-6) → 4-hydroxymethyl-1,3-dioxolan-2-one (931-40-8) + (2-oxo-1,3-dioxolan-4-yl)methyl carbamate (855687-99-9) + 4-Hydroxymethyl oxazolidin-2-one (15546-08-4)

Guidance literature:

With Zn₂CrO; at 140 ℃; for 3h; under 22.5023 Torr; Reagent/catalyst;

DOI:10.1016/j.cattod.2019.09.017

Reference yield: 52.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + urea (57-13-6) → 4-hydroxymethyl-1,3-dioxolan-2-one (931-40-8) + 2,3-dihydroxypropyl carbamate (223754-90-3) + (2-oxo-1,3-dioxolan-4-yl)methyl carbamate (855687-99-9) + 4-Hydroxymethyl oxazolidin-2-one (15546-08-4)

Guidance literature:

With Zn₂CoO; at 140 ℃; for 3h; under 22.5023 Torr; Reagent/catalyst;

DOI:10.1016/j.cattod.2019.09.017

upstream raw materials:

glycerol

urea

Downstream raw materials:

2-oxo-1,3-oxazolidin-4-ylmethyl p-toluenesulfonate

(4R)-4-(hydroxymethyl)-1,3-oxazolidin-2-one

(4S)-4-(hydroxymethyl)-1,3-oxazolidin-2-one