(+)-3,4-Dihydro-3-methylisoquinoline

Base Information

• Chemical Name: (+)-3,4-Dihydro-3-methylisoquinoline
• CAS No.: 15547-41-8
• Molecular Formula: C10H11N
• Molecular Weight: 145.20100
• Mol file: 15547-41-8.mol

Synonyms:(R)-3-Methyl-3,4-dihydro-isoquinoline;

Chemical Property of (+)-3,4-Dihydro-3-methylisoquinoline

Chemical Property:

• PSA: 12.36000
• LogP: 1.48570

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-METHYL 3,4-DIHYDROISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-3,4-Dihydro-3-methylisoquinoline

There total 3 articles about (+)-3,4-Dihydro-3-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-(1-methyl-2-phenylethyl)formamide (15302-18-8) → (R)-3-methyl-3,4-dihydroisoquinoline (15547-41-8)

Guidance literature:

With PPA; at 170 ℃; for 1.5h;

DOI:10.1021/jm0401356

Reference yield:

(-)-Amphetamine hydrochloride (41820-21-7,405-41-4) → (R)-3-methyl-3,4-dihydroisoquinoline (15547-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / Et₃N / ethanol / 48 h / Heating

2: polyphosphoric acid / 1.5 h / 170 °C

With PPA; triethylamine; In ethanol; 2: Bischler-Napieralski cyclization;

DOI:10.1021/jm0401356

Reference yield:

formic acid (64-18-6) + dexamfetamine (51-64-9,17108-96-2,96332-84-2) → (R)-3-methyl-3,4-dihydroisoquinoline (15547-41-8)

Guidance literature:

With phosphoric acid; phosphorus pentoxide; 1.) 180 deg C, 4 h, 2.) 200 deg C, 3 h;

upstream raw materials:

formic acid

dexamfetamine

(R)-N-(1-methyl-2-phenylethyl)formamide

(-)-Amphetamine hydrochloride

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