N-(5-CHLORO-2-HYDROXY-3-NITROPHENYL)ACETAMIDE

Base Information

• Chemical Name: N-(5-CHLORO-2-HYDROXY-3-NITROPHENYL)ACETAMIDE
• CAS No.: 156016-33-0
• Molecular Formula: C8H7ClN2O4
• Molecular Weight: 230.608
• Hs Code.: 2924299090
• Mol file: 156016-33-0.mol

Synonyms:4-Chlor-6-nitro-2-acetamino-phenol;2-acetamino-4-chloro-6-nitrophenol;acetic acid-(5-chloro-2-hydroxy-3-nitro-anilide);Essigsaeure-(5-chlor-2-hydroxy-3-nitro-anilid);

Chemical Property of N-(5-CHLORO-2-HYDROXY-3-NITROPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >161°C (dec)
• Boiling Point: 366.686oC at 760 mmHg
• Flash Point: 175.566oC
• PSA: 98.64000
• Density: 1.593g/cm3
• LogP: 3.08490
• Storage Temp.: Refrigerator
• Solubility.: Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

N-(5-Chloro-2-hydroxy-3-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(5-Chloro-2-hydroxy-3-nitrophenyl)acetamide (cas# 156016-33-0) is a compound useful in organic synthesis.

Technology Process of N-(5-CHLORO-2-HYDROXY-3-NITROPHENYL)ACETAMIDE

There total 4 articles about N-(5-CHLORO-2-HYDROXY-3-NITROPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(5-chloro-2-hydroxyphenyl)acetamide (26488-93-7) → acetic acid-(5-chloro-2-hydroxy-3-nitro-anilide) (156016-33-0)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 0 - 26 ℃; for 2.75h;

Reference yield:

4-chloro-6-nitro-2-aminophenol (6358-08-3) + acetic anhydride (108-24-7) → acetic acid-(5-chloro-2-hydroxy-3-nitro-anilide) (156016-33-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

Reference yield:

2-hydroxy-5-chloro-aniline (95-85-2) → acetic acid-(5-chloro-2-hydroxy-3-nitro-anilide) (156016-33-0)

Guidance literature:

Multi-step reaction with 2 steps

2: nitric acid / 25 - 50 °C

With nitric acid;

upstream raw materials:

N-(5-chloro-2-hydroxyphenyl)acetamide

nitric acid

2-hydroxy-5-chloro-aniline

4-chloro-6-nitro-2-aminophenol

Downstream raw materials:

C₂₄H₂₂Cl₂F₃N₅O₃

4-chloro-6-nitro-2-aminophenol

Refernces

• 1、 -. "Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same". Page/Page column 6. . Retrieved 2008/06/13.
• 2、 -. "STABLE CRYSTALLINE FORM OF BIFEPRUNOX MESYLATE (7-[4-([1,1'-BIPHENYL]-3-YLMETHEYL)-1-PIPERAZINYL]-2(3H)-BENZOXAZOLONE MONOMETHANESULFONATE". Page/Page column 10. . Retrieved 2010/02/10.