26488-93-7

Basic information

• Product Name: N-(5-chloro-2-hydroxyphenyl)acetamide
• Synonyms: N-(5-chloro-2-hydroxyphenyl)acetamide;4-Chloro-2-(acetylamino)phenol;5'-Chloro-2'-hydroxyacetanilide;5-Chloro-2-hydroxyacetanilide;N-(2-Hydroxy-5-chlorophenyl)acetamide;2-acetylamino-4-chlorophenol;4-Chloro-2-acetamidophenol;Acetamide, N-(5-chloro-2-hydroxyphenyl)-
• CAS NO: 26488-93-7
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.60762
• EINECS: 247-736-0
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 26488-93-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 182-184°C
• Boiling Point: 366.99 °C at 760 mmHg
• Flash Point: 175.749 °C
• Appearance: /
• Density: 1.397 g/cm³
• Vapor Pressure: 6.67E-06mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 8.82±0.48(Predicted)
• CAS DataBase Reference: N-(5-chloro-2-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-chloro-2-hydroxyphenyl)acetamide(26488-93-7)
• EPA Substance Registry System: N-(5-chloro-2-hydroxyphenyl)acetamide(26488-93-7)

Safety Data

• Hazardous Substances Data: 26488-93-7(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

InChI:InChI=1/C8H8ClNO2/c1-5(11)10-7-4-6(9)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)

Upstream product

• 87049-66-9 2'-amino-5'-chloroacetanilide 
• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 60-35-5 acetamide 
• 75-36-5 acetyl chloride 
• 123-54-6 acetylacetone 
• 614-80-2 2-(acetylamino)phenol 
• 36637-30-6 O-(4-chlorophenyl)hydroxylamine 
• 220464-84-6 (p-chloro-N-phenoxy)phthalimide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 3964-52-1 2-chloro 4-aminophenol 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 860675-48-5 acetic acid-[5-chloro-2-(2-diethylamino-ethoxy)-anilide] 
• 156016-33-0 acetic acid-(5-chloro-2-hydroxy-3-nitro-anilide) 
• 676131-84-3 2-acetylamino-4-chloro-6-(2-chlorobenzoyl)phenol 
• 676131-85-4 2-acetylamino-4-chloro-6-(4-chlorobenzoyl)phenol 
• 868408-04-2 N-(5-chloro-2-{2-[7-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl]-2-oxoethoxy}-phenyl)acetamide 
• 1221498-22-1 N-(2-(allyloxy)-5-chlorophenyl)acetamide 
• 1296885-50-1 N-[5-chloro-2-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-acetamide 
• 1296885-47-6 trifluoromethanesulfonic acid 2-acetylamino-4-chloro-phenyl ester 
• 28763-40-8 N-(5-Chloro-2-oxiranylmethoxy-phenyl)-acetamide 
• 644968-90-1 N-{5-chloro-2-[(2S)-oxiran-2-ylmethoxy]phenyl}acetamide 
• 96079-86-6 5-chloro-2-(2-diethylamino-ethoxy)-aniline 
• 6358-08-3 4-chloro-6-nitro-2-aminophenol 
• 676131-96-7 ethyl 4-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate 
• 676131-97-8 ethyl 4-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]butanoate 

Relevant articles and documents

Iron(III)-Mediated Nucleophilic Halogenation of Phenols Using an Amido Directing Group

A regioselective and nucleophilic halogenation of electron-rich amidophenols was realized in the presence of Fe(III) reagents and amido-directing groups. Halides could be sequentially introduced to specific positions to form mono-, di- and mixed di- halogenated amidophenols. Furthermore, this protocol provides new methods for the syntheses of IKK2 inhibitor (IMD-0354), muscle relaxant (Chlorzoxazone) and related derivatives.

Chiral N,N Ligands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck–Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions

Unprecedented enantioselective intramolecular Heck carbonylation reactions of arenediazonium salts were enabled by a chiral N,N ligand. This reaction constitutes the first enantioselective Heck carbonylation that proceeds through migratory insertion followed by CO insertion. The enantioenriched functionalized dihydrobenzofurans were obtained in good to high yields and enantiomeric ratios of up to 98:2 under mild and operationally simple reaction conditions.

Synthesis of benzoxazoles from 2-aminophenols and β-diketones using a combined catalyst of br?nsted acid and copper iodide

Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Br?nsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions.