Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-

Base Information

Chemical Name:Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-
CAS No.:156972-89-3
Molecular Formula:C10H13BrN2O3S
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID00453613
Wikidata:Q82274795
Mol file:156972-89-3.mol

Synonyms:156972-89-3;Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-;SCHEMBL7706771;DTXSID00453613

Suppliers and Price of Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:319.98303
Heavy Atom Count:17
Complexity:353

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCNC(=O)NS(=O)(=O)C1=CC=CC=C1Br

Technology Process of Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]-

There total 1 articles about Benzenesulfonamide, 2-bromo-N-[(propylamino)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-78-1
Propyl isocyanate

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 156972-89-3
1-bromo-N-[(propylamino)carbonyl]benzene-2-sulfonamide

Guidance literature:: With potassium carbonate; Yield given. Multistep reaction; 1.) DME, reflux, 1 h, 2.) DME, reflux, 12 h;
DOI:10.1055/s-1996-4383

Reference yield:

: 156972-89-3
1-bromo-N-[(propylamino)carbonyl]benzene-2-sulfonamide

: 144628-52-4
2-butyl-4-(methylthio)-1-[[2'-((((propylamino)-carbonyl)-amino)-sulfonyl)-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Ph₃P, Cs₂CO₃, Pd(OAc)2 / 1.) toluene, H₂O, 60 deg C, 10 min, 2.) toluene, H₂O, 75 deg C, 5 h

2: CH₂Cl₂ / 6 h / 35 °C

3: NaBH(OAc)3 / CH₂Cl₂ / 16 h

4: 40 percent / K₂CO₃ / acetone / 6 h / Ambient temperature

5: 86 percent / Et₃N / CH₂Cl₂ / 48 h / 40 °C / 7500.6 Torr

6: 76 percent / conc. H₂SO₄ / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

7: 93 percent / aq. NaOH / methanol / 18 h / Ambient temperature

With palladium diacetate; sodium hydroxide; sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In methanol; 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1055/s-1996-4383

Reference yield:

: 156972-89-3
1-bromo-N-[(propylamino)carbonyl]benzene-2-sulfonamide

: 144628-51-3
ethyl 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Ph₃P, Cs₂CO₃, Pd(OAc)2 / 1.) toluene, H₂O, 60 deg C, 10 min, 2.) toluene, H₂O, 75 deg C, 5 h

2: CH₂Cl₂ / 6 h / 35 °C

3: NaBH(OAc)3 / CH₂Cl₂ / 16 h

4: 40 percent / K₂CO₃ / acetone / 6 h / Ambient temperature

5: 86 percent / Et₃N / CH₂Cl₂ / 48 h / 40 °C / 7500.6 Torr

6: 76 percent / conc. H₂SO₄ / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With palladium diacetate; sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1055/s-1996-4383