2-[(4-Fluorophenyl)carbonyl]furan

Base Information

• Chemical Name: 2-[(4-Fluorophenyl)carbonyl]furan
• CAS No.: 15817-51-3
• Molecular Formula: C11H7FO2
• Molecular Weight: 190.174
• DSSTox Substance ID: DTXSID60415459
• Nikkaji Number: J2.282.552F
• Wikidata: Q82224397
• Mol file: 15817-51-3.mol

Synonyms:15817-51-3;2-[(4-fluorophenyl)carbonyl]furan;(4-fluorophenyl)(2-furyl)methanone;(4-fluorophenyl)-(furan-2-yl)methanone;2-(4-Fluorobenzoyl)furan;(4-fluorophenyl)(furan-2-yl)methanone;Methanone, (4-fluorophenyl)-2-furanyl-;SCHEMBL16713290;DTXSID60415459;QUGYNSZHLOWNLK-UHFFFAOYSA-N;MFCD07658237;STK736433;AKOS003389130;Methanone, (4-fluorophenyl)2-furanyl-;BB 0221026;CS-0262905;EN300-84217;Z425399812

Chemical Property of 2-[(4-Fluorophenyl)carbonyl]furan

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.04300762
• Heavy Atom Count: 14
• Complexity: 209

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C(=O)C2=CC=C(C=C2)F

Technology Process of 2-[(4-Fluorophenyl)carbonyl]furan

There total 4 articles about 2-[(4-Fluorophenyl)carbonyl]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-furancarbonyl chloride (527-69-5) + tris(4-fluorophenyl)bismuthane (437-29-6) → (4-fluorophenyl)(furan-2-yl)methanone (15817-51-3)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 3h;

DOI:10.1016/j.tet.2007.10.047

Reference yield: 86.0%

N-methoxy-N-methyl-2-furancarboxamide (95091-92-2) + 4-flourophenylmagnesium bromide (352-13-6) → (4-fluorophenyl)(furan-2-yl)methanone (15817-51-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0030-1258247

Reference yield: 80.0%

fur-2-ylboronic acid (13331-23-2) + 4-Fluorobenzoic acid (456-22-4) → (4-fluorophenyl)(furan-2-yl)methanone (15817-51-3)

Guidance literature:

With P(p-CH₃OC₆H₄)3; carbonic acid dimethyl ester; palladium diacetate; In tetrahydrofuran; water; at 40 ℃; for 24h;

DOI:10.1016/j.tetlet.2005.12.122

upstream raw materials:

fur-2-ylboronic acid

4-Fluorobenzoic acid

2-furancarbonyl chloride

tris(4-fluorophenyl)bismuthane

Downstream raw materials:

5-[5-(4-fluorobenzoyl)furan-2-yl]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

ethyl 4-[5-(4-fluorobenzoyl)furan-2-yl]benzoate

methyl 4-[5-(4-fluorobenzoyl)furan-2-yl]-2-hydroxybenzoate

4-[5-(4-fluorobenzoyl)furan-2-yl]benzonitrile