(S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate
CAS No.:158392-80-4
Molecular Formula:C14H23NO5
Molecular Weight:285.33600
Hs Code.:
Mol file:158392-80-4.mol

Synonyms:Ethyl (2S)-1-(tert-butoxycarbonyl)-4,4-dimethylpyroglutamate;(S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate;(S)-4,4-Dimethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester;

Suppliers and Price of (S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-1-tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 95+%
1g
$ 369.00

Crysdot
(S)-1-tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 95+%
5g
$ 1293.00

Chemenu
Ethyl(S)-1-Boc-4,4-dimethyl-5-oxopyrrolidine-2-carboxylate 95%
5g
$ 1572.00

Alichem
(S)-1-tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate
5g
$ 1190.33

Alichem
(S)-1-tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate
1g
$ 339.63

AK Scientific
(S)-1-Tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate
5g
$ 2106.00

AK Scientific
(S)-1-Tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate
1g
$ 752.00

AK Scientific
(S)-1-Tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate
250mg
$ 346.00

Total 9 raw suppliers

Chemical Property of (S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate

Chemical Property:

Boiling Point:383.5±35.0 °C(Predicted)
PKA:-4.06±0.60(Predicted)
PSA：72.91000
Density:1.114±0.06 g/cm3(Predicted)
LogP:2.04960
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-tert-Butyl2-ethyl4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate

There total 6 articles about (S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 144978-35-8,144978-12-1,251924-83-1
(S)-ethyl N-tert-butoxycarbonylpyroglutamate

: 74-88-4
methyl iodide

: 158392-80-4
1-tert-butyl 2-ethyl (2S)4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: (S)-ethyl N-tert-butoxycarbonylpyroglutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 - 25 ℃; for 2.25h;

Reference yield: 37.0%

: 144978-35-8,144978-12-1,251924-83-1
(S)-ethyl N-tert-butoxycarbonylpyroglutamate

: 74-88-4
methyl iodide

: 158392-80-4
1-tert-butyl 2-ethyl (2S)4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate

: 553679-43-9
(2S,4R)-4-Methyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 553679-44-0
ethyl (2S,4S)-N-tert-butoxycarbonyl-4-methylpyroglutamate

Guidance literature:: (S)-ethyl N-tert-butoxycarbonylpyroglutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h;

methyl iodide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(03)00429-5