(2S)-4,4-diMethyl-2-PyrrolidineMethanol

Base Information

• Chemical Name: (2S)-4,4-diMethyl-2-PyrrolidineMethanol
• CAS No.: 212890-85-2
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.202
• Mol file: 212890-85-2.mol

Synonyms:(2S)-4,4-diMethyl-2-PyrrolidineMethanol;2-PyrrolidineMethanol, 4,4-diMethyl-, (2S)-;((S)-4,4-dimethylpyrrolidin-2-yl)methanol

Chemical Property of (2S)-4,4-diMethyl-2-PyrrolidineMethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

((S)-4,4-Dimethylpyrrolidin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-4,4-diMethyl-2-PyrrolidineMethanol

There total 7 articles about (2S)-4,4-diMethyl-2-PyrrolidineMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-ethyl 4,4-dimethyl-5-oxopyrrolidine-2-carboxylate (221637-35-0) → (S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol (212890-85-2)

Guidance literature:

(S)-ethyl 4,4-dimethyl-5-oxopyrrolidine-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 8h; Reflux;

With water; sodium hydroxide;

Reference yield: 82.0%

(5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one (156088-46-9) → (S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol (212890-85-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)01783-2

Reference yield: 66.0%

1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine (1094359-30-4) → (S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol (212890-85-2)

Guidance literature:

1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine; With ammonia; lithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

With water; ammonium chloride; zinc; In methanol; at 80 ℃; for 24h;

DOI:10.1021/ja806585m

upstream raw materials:

(5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one

(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

(5S)-1-aza-2,2-dimethyl-7,7-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

Downstream raw materials:

(S)-2-[(Diphenylphosphanyl)-methyl]-4,4-dimethyl-pyrrolidine

(S)-(-)-tert-butyl 4,4-dimethyl-2-[((4-methylphenyl)sulfonyloxy)methyl]pyrrolidinecarboxylate

(S)-(-)-tert-butyl 2-[(diphenylphosphino)methyl]-4,4-dimethylpyrrolidinecarboxylate

4,4-dimethyl-L-proline

Refernces

• 1、 -. "TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES". . . Retrieved 2012/04/17.
• 2、 -. "FUSED TETRACYCLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES". . . Retrieved 2012/05/04.