2,4,5-TRIMETHYLPHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 2,4,5-TRIMETHYLPHENYLMAGNESIUM BROMIDE
• CAS No.: 160727-03-7
• Molecular Formula: C9H11BrMg
• Molecular Weight: 223.39300
• Mol file: 160727-03-7.mol

Synonyms:Magnesium,bromo(2,4,5-trimethylphenyl);2,3-DIHYDRO-5-(TRIFLUOROMETHYL)FURAN;2,4,5-Trimethylphenylmagnesium bromide 0.5 M in Tetrahydrofuran;

Chemical Property of 2,4,5-TRIMETHYLPHENYLMAGNESIUM BROMIDE

Chemical Property:

• PSA: 0.00000
• LogP: 3.25760

Purity/Quality:

99.90% ^*data from raw suppliers

2,4,5-Trimethylphenylmagnesiumbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,5-TRIMETHYLPHENYLMAGNESIUM BROMIDE

There total 1 articles about 2,4,5-TRIMETHYLPHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2,4,5-trimethylbenzene (5469-19-2) → (2,4,5-trimethylphenyl)magnesium bromide (160727-03-7)

Guidance literature:

With magnesium; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1002/anie.201206556

Reference yield:

(2,4,5-trimethylphenyl)magnesium bromide (160727-03-7) → 1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene (1428266-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogenchloride; water / tetrahydrofuran / 1 h / Inert atmosphere

2: copper(II) chloride dihydrate / 1,4-dioxane; water / 12 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) chloride dihydrate; water; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1002/anie.201206556

Reference yield:

(2,4,5-trimethylphenyl)magnesium bromide (160727-03-7) → C52H58MnO

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Schlenk technique; Inert atmosphere; Glovebox

1.2: -78 °C / Schlenk technique; Inert atmosphere; Glovebox; Reflux

1.3: 1 h / Schlenk technique; Inert atmosphere; Glovebox

2.1: n-butyllithium / hexane / 0 - 20 °C

3.1: toluene / 16 h / 20 °C / Schlenk technique; Glovebox; Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane; toluene;

DOI:10.1039/C6CC07243G

upstream raw materials:

1-bromo-2,4,5-trimethylbenzene

Downstream raw materials:

3-(2,4,5-trimethylphenyl)but-3-enoic acid

1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

Refernces

• 1、 He, Zhengbiao,Hu, Mingyou,Luo, Tao,Li, Lingchun,Hu, Jinbo. "Copper-catalyzed difluoromethylation of β,γ-unsaturated carboxylic acids: An efficient allylic difluoromethylation". supporting information. p. 11545 - 11547. Retrieved 2013/01/15.