1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

Base Information

Chemical Name:1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene
CAS No.:1428266-92-5
Molecular Formula:C₁₉H₂₀F₂O₂S
Molecular Weight:350.429
Hs Code.:

Synonyms:1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

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Technology Process of 1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

There total 3 articles about 1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1052174-67-0
C₁₆H₁₅F₂IO₃S

: 1428266-76-5
3-(2,4,5-trimethylphenyl)but-3-enoic acid

: 1428266-92-5
1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

Guidance literature:: With copper(II) chloride dihydrate; In 1,4-dioxane; water; at 90 ℃; for 12h;
DOI:10.1002/anie.201206556

Reference yield:

: 5469-19-2
1-bromo-2,4,5-trimethylbenzene

: 1428266-92-5
1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium / tetrahydrofuran / 1.5 h / 20 °C

2: zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogenchloride; water / tetrahydrofuran / 1 h / Inert atmosphere

3: copper(II) chloride dihydrate / 1,4-dioxane; water / 12 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) chloride dihydrate; water; magnesium; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1002/anie.201206556

Reference yield:

: 160727-03-7
(2,4,5-trimethylphenyl)magnesium bromide

: 1428266-92-5
1-(4,4-difluoro-4-(phenylsulfonyl)but-1-en-2-yl)-2,4,5-trimethylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogenchloride; water / tetrahydrofuran / 1 h / Inert atmosphere

2: copper(II) chloride dihydrate / 1,4-dioxane; water / 12 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) chloride dihydrate; water; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1002/anie.201206556