4-Bromo-3'-fluoro-4'-methoxybenzophenone

Base Information

• Chemical Name: 4-Bromo-3'-fluoro-4'-methoxybenzophenone
• CAS No.: 161581-93-7
• Molecular Formula: C14H10BrFO2
• Molecular Weight: 309.135
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID70373672
• Wikidata: Q82161951
• Mol file: 161581-93-7.mol

Synonyms:4-Bromo-3'-fluoro-4'-methoxybenzophenone;161581-93-7;(4-bromophenyl)-(3-fluoro-4-methoxyphenyl)methanone;(4-bromophenyl)(3-fluoro-4-methoxyphenyl)methanone;4-BROMO-3-FLUORO-4/'-METHOXYBENZOPHENONE;SCHEMBL3468365;DTXSID70373672;GHUMLKAJACJMCH-UHFFFAOYSA-N;MFCD06201453;AKOS009529879;4-Bromo-3/'-fluoro-4/'-methoxybenzophenone;(4-Bromo-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone

Chemical Property of 4-Bromo-3'-fluoro-4'-methoxybenzophenone

Chemical Property:

• Vapor Pressure: 7.11E-07mmHg at 25°C
• Boiling Point: 408.2oC at 760 mmHg
• Flash Point: 200.7oC
• PSA: 26.30000
• Density: 1.458g/cm3
• LogP: 3.82780
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 307.98482
• Heavy Atom Count: 18
• Complexity: 290

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-3'-fluoro-4'-methoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F

Technology Process of 4-Bromo-3'-fluoro-4'-methoxybenzophenone

There total 2 articles about 4-Bromo-3'-fluoro-4'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-bromo-N-methoxy-N-methylbenzamide (192436-83-2) → (4-bromo-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone (161581-93-7)

Guidance literature:

3-fluoro-4-methoxyphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

4-bromo-N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexanes; at -20 ℃; for 1h;

Reference yield:

1-fluoro-2-methoxybenzene (321-28-8) + 4-chlorobenzoyl chloride (586-75-4) → (4-bromo-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone (161581-93-7)

Guidance literature:

upstream raw materials:

4-bromo-N-methoxy-N-methylbenzamide

1-fluoro-2-methoxybenzene

4-chlorobenzoyl chloride

Refernces

• 1、 -. "Amino alkenyloxybenzene derivatives". . . Retrieved 2008/06/13.