Technology Process of Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-2-propenyl-,
1,1-dimethylethyl ester
There total 6 articles about Carbamic acid, [1-iodo-4-(phenylmethoxy)-2-naphthalenyl]-2-propenyl-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl-(4-(benzyloxy)-1-iodonaphthalen-2-yl)carbamate;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.0833333h;
allyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / N-iodosuccinimide, H2SO4 / tetrahydrofuran; methanol / 3 h / -78 °C
2: 95 percent / NaH / dimethylformamide / 1.) 0 deg C, 45 min, 2.) 25 deg C, 3 h
With
N-iodo-succinimide; sulfuric acid; sodium hydride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00110a034
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen bromide; acetic acid / water / 24 h / 100 °C / Inert atmosphere
1.2: 4 h / 100 °C / Inert atmosphere
2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 3 h
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h
4.1: N-iodo-succinimide; toluene-4-sulfonic acid / water; tetrahydrofuran; methanol / 1 h / -78 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h
5.2: 0.5 h
With
N-iodo-succinimide; water; hydrogen bromide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
