4-Bromo-1-isopropoxy-2-vinylbenzene

Base Information

• Chemical Name: 4-Bromo-1-isopropoxy-2-vinylbenzene
• CAS No.: 16602-27-0
• Molecular Formula: C11H13BrO
• Molecular Weight: 241.128
• DSSTox Substance ID: DTXSID20501903
• Nikkaji Number: J1.334.256C
• Wikidata: Q82354599
• Mol file: 16602-27-0.mol

Synonyms:16602-27-0;4-bromo-1-isopropoxy-2-vinylbenzene;4-bromo-2-ethenyl-1-propan-2-yloxybenzene;Benzene, 4-bromo-2-ethenyl-1-(1-methylethoxy)-;4-bromo-2-ethenyl-1-(propan-2-yloxy)benzene;SCHEMBL314775;DTXSID20501903;ALZZHCKOFMJWES-UHFFFAOYSA-N;AMY30941;4-Bromo-1-isopropoxy-2-vinyl-benzene;4-Bromo-2-ethenyl-1-[(propan-2-yl)oxy]benzene;A902935;A1-32932

Chemical Property of 4-Bromo-1-isopropoxy-2-vinylbenzene

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 240.01498
• Heavy Atom Count: 13
• Complexity: 168

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)OC1=C(C=C(C=C1)Br)C=C

Technology Process of 4-Bromo-1-isopropoxy-2-vinylbenzene

There total 6 articles about 4-Bromo-1-isopropoxy-2-vinylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 2-(2-propoxy)-5-bromobenzaldehyde (138505-25-6) → 4-bromo-1-isopropoxy-2-vinylbenzene (16602-27-0)

Guidance literature:

With n-butyllithium; ammonium chloride; In tetrahydrofuran;

Reference yield: 91.0%

2-(2-propoxy)-5-bromobenzaldehyde (138505-25-6) + Methylenetriphenylphosphorane (19493-09-5) → 4-bromo-1-isopropoxy-2-vinylbenzene (16602-27-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/hlca.200590087

Reference yield: 69.0%

2-iodo-propane (75-30-9) + Methylenetriphenylphosphorane (19493-09-5) + 5-bromosalicyclaldehyde (1761-61-1) → 4-bromo-1-isopropoxy-2-vinylbenzene (16602-27-0)

Guidance literature:

2-iodo-propane; 5-bromosalicyclaldehyde; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Methylenetriphenylphosphorane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1016/S0040-4039(02)02283-9

upstream raw materials:

2-iodo-propane

Methylenetriphenylphosphorane

5-bromosalicyclaldehyde

2-(2-propoxy)-5-bromobenzaldehyde

Downstream raw materials:

ethyl (4-fluorophenyl)-[4-{isopropoxy}-3-vinylphenyl]-phosphinate

ethyl phenyl-{4-(isopropoxy)-3-vinylphenyl}phosphinate

4-isopropoxy-3-vinylbenzaldehyde