1-BOC-4-PHENYL-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 1-BOC-4-PHENYL-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER
• CAS No.: 167262-47-7
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.401
• Mol file: 167262-47-7.mol

Synonyms:1-tert-butoxycarbonyl-4-methoxycarbonyl-4-phenylpiperidine;1-Boc-4-phenyl-4-methoxycarbonylpiperidine;

Chemical Property of 1-BOC-4-PHENYL-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 55.84000
• LogP: 3.06620

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Boc-4-phenyl-4-methoxycarbonylpiperidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-PHENYL-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER

There total 3 articles about 1-BOC-4-PHENYL-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid (167262-68-2) + diazomethyl-trimethyl-silane (18107-18-1) → 1-tert-butyloxycarbonyl-4-phenyl-piperidine-4-carboxylic acid methyl ester (167262-47-7)

Guidance literature:

With methanol; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

Reference yield:

N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid (167262-68-2) + methyl iodide (74-88-4) → 1-tert-butyloxycarbonyl-4-phenyl-piperidine-4-carboxylic acid methyl ester (167262-47-7)

Guidance literature:

N-ethyl-N,N-diisopropylamine; In acetonitrile;

Reference yield:

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine (118753-70-1) + benzeneacetic acid methyl ester (101-41-7) → 1-tert-butyloxycarbonyl-4-phenyl-piperidine-4-carboxylic acid methyl ester (167262-47-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/S0960-894X(00)00307-3

upstream raw materials:

N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

benzeneacetic acid methyl ester

N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

methyl iodide

Downstream raw materials:

3-[4-methoxycarbonyl-4-phenyl piperidin-1-yl]propylamine

methyl 4-phenylpiperidine-4-carboxylate

Refernces

• 1、 Patane, Michael A.,DiPardo, Robert M.,Newton, Randall C.,Price, RoseAnn P.,Broten, Theodore P.,Chang, Raymond S.L.,Ransom, Richard W.,Di Salvo, Jerry,Nagarathnam, Dhanapalan,Forray, Carlos,Gluchowski, Charles,Bock, Mark G.. "Phenylacetamides as selective α-1A adrenergic receptor antagonists". . p. 1621 - 1624. Retrieved 2007/10/03.
• 2、 -. "SUBSTITUTED PYRROLIDIN-3-YL-ALKYL-PIPERIDINES". . . Retrieved 2008/06/13.