2-(2-amino-9-propyl-purin-6-yl)sulfanylacetic acid

Base Information

• Chemical Name: 2-(2-amino-9-propyl-purin-6-yl)sulfanylacetic acid
• CAS No.: 42204-31-9
• Molecular Formula: C₁₀H₁₃N₅O₂S
• Molecular Weight: 267.312
• Hs Code.: 2933990090
• Mol file: 42204-31-9.mol

Synonyms:Aceticacid, [(2-amino-9-propyl-9H-purin-6-yl)thio]- (7CI,9CI); NSC 51470

Chemical Property of 2-(2-amino-9-propyl-purin-6-yl)sulfanylacetic acid

Chemical Property:

• Vapor Pressure: 8.05E-15mmHg at 25°C
• Boiling Point: 591.2°Cat760mmHg
• Flash Point: 311.3°C
• PSA: 132.22000
• Density: 1.6g/cm³
• LogP: 1.57640

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-amino-9-propyl-purin-6-yl)sulfanylacetic acid

There total 6 articles about 2-(2-amino-9-propyl-purin-6-yl)sulfanylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl [(2-amino-9-propyl-9H-purin-6-yl)sulfanyl]acetate (1263893-57-7) → 9-Propyl-2-amino-6-carboxymethylmercapto-9H-purin (42204-31-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

2-Amino-6-chloropurin (10310-21-1) → 9-Propyl-2-amino-6-carboxymethylmercapto-9H-purin (42204-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 5 h / 0 °C

2.1: sodium methylate / water / 6 h / 70 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

With sodium methylate; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

2-amino-6-chloro-9-propyl-9H-purine → 9-Propyl-2-amino-6-carboxymethylmercapto-9H-purin (42204-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / water / 6 h / 70 °C

2: sodium hydroxide / tetrahydrofuran; water / 20 °C

With sodium methylate; sodium hydroxide; In tetrahydrofuran; water;

upstream raw materials:

thioguanine

methyl [(2-amino-9-propyl-9H-purin-6-yl)sulfanyl]acetate

methyl [(2-amino-7-propyl-7H-purin-6-yl)sulfanyl]acetate

2-Amino-6-chloropurin

Refernces