Technology Process of Spiro[2.4]hept-5-ene,
5-(3,4-dichlorophenyl)-6-[4-(methylsulfonyl)phenyl]-
There total 10 articles about Spiro[2.4]hept-5-ene,
5-(3,4-dichlorophenyl)-6-[4-(methylsulfonyl)phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium iodide; zinc;
In
N,N-dimethyl-formamide;
at 150 ℃;
for 3h;
DOI:10.1021/jm950664x
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 63.3 percent / K2CO3, KI / tetrahydrofuran / 6 h / Ambient temperature
2: K2CO3, KI / tetrahydrofuran
3: TiCl3, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating
4: DIBAL / tetrahydrofuran / 0.25 h / -78 °C
5: pyridine / Ambient temperature
6: NaI, zinc dust / dimethylformamide / 3 h / 150 °C
With
pyridine; titanium(III) chloride; diisobutylaluminium hydride; potassium carbonate; potassium iodide; sodium iodide; zinc;
In
tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950664x
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 91 percent / mCPBA / CH2Cl2 / Ambient temperature
2: 15.7 g / HCl, bromine / acetic acid
3: 63.3 percent / K2CO3, KI / tetrahydrofuran / 6 h / Ambient temperature
4: K2CO3, KI / tetrahydrofuran
5: TiCl3, zinc dust / 1,2-dimethoxy-ethane / 1 h / Heating
6: DIBAL / tetrahydrofuran / 0.25 h / -78 °C
7: pyridine / Ambient temperature
8: NaI, zinc dust / dimethylformamide / 3 h / 150 °C
With
pyridine; hydrogenchloride; titanium(III) chloride; bromine; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; sodium iodide; zinc;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm950664x
