Zicronapine

Base Information

Chemical Name:Zicronapine
CAS No.:170381-16-5
Deprecated CAS:846541-63-7
Molecular Formula:C22H27ClN2
Molecular Weight:354.923
Hs Code.:
UNII:QZV11V7G6A
ChEMBL ID:CHEMBL3039528
DSSTox Substance ID:DTXSID30168849
Metabolomics Workbench ID:153222
NCI Thesaurus Code:C152950
Nikkaji Number:J3.492.823A
Pharos Ligand ID:YDHTXS5AXTNS
Wikidata:Q8071477
Wikipedia:Zicronapine
Mol file:170381-16-5.mol

Synonyms:Zicronapine;170381-16-5;QZV11V7G6A;4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine;LU 31-130;LU-31-130;4-((1R,3S)-6-Chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine;UNII-QZV11V7G6A;Piperazine, 4-[(1R,3S)-6-chloro-2,3-dihydro-3-phenyl-1H-inden-1-yl]-1,2,2-trimethyl-;Zicronapine [INN];Zicronapine [USAN:INN];Piperazine, 4-((1R,3S)-6-chloro-2,3-dihydro-3-phenyl-1H-inden-1-yl)-1,2,2-trimethyl-;Zicronapine (USAN/INN);ZICRONAPINE [USAN];ZICRONAPINE [WHO-DD];SCHEMBL904402;CHEMBL3039528;DTXSID30168849;CHEBI:177409;BDBM50547397;AKOS032946690;DB12188;HY-14827;CS-0003579;NS00071675;D10329;Q8071477

Suppliers and Price of Zicronapine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of Zicronapine

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:354.1862766
Heavy Atom Count:25
Complexity:459

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CN(CCN1C)C2CC(C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
Isomeric SMILES:CC1(CN(CCN1C)[C@@H]2C[C@H](C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
Recent ClinicalTrials:Efficacy of Lu 31-130 in Patients With Schizophrenia
Recent EU Clinical Trials:A 6-month, randomised, double-blind, parallel-group, risperidone-controlled, fixed-dose study evaluating the safety and efficacy of zicronapine in patients with schizophrenia

Technology Process of Zicronapine

There total 11 articles about Zicronapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 846052-64-0
trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 846061-48-1
cis-4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine

: 170381-16-5
Zicronapine

Guidance literature:: trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine; formaldehyd; With formic acid; In water; at 110 ℃; for 1.5h;

With sodium hydroxide; In water; at 20 ℃; pH=14;

Reference yield:

: 846052-64-0
trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 64-18-6
formic acid

: 846061-48-1
cis-4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine

: 170381-16-5
Zicronapine

Guidance literature:: trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine; formaldehyd; formic acid; In water; at 60 ℃; for 3.5h; Heating / reflux;

With hydrogenchloride; In water; at 20 ℃;