3H-Imidazo[4,5-b]pyridine-2-methanol, 3-methyl-5-(phenylthio)-

Base Information

Chemical Name:3H-Imidazo[4,5-b]pyridine-2-methanol, 3-methyl-5-(phenylthio)-
CAS No.:172648-62-3
Molecular Formula:C14H13N3OS
Molecular Weight:271.33800
Hs Code.:
Mol file:172648-62-3.mol

Synonyms:(3-Methyl-5-phenylsulfanyl-3H-imidazo[4,5-b]pyridin-2-yl)-methanol;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3H-Imidazo[4,5-b]pyridine-2-methanol, 3-methyl-5-(phenylthio)-

Chemical Property:

Melting Point:119 - 120 °C
Boiling Point:512.2±40.0 °C(Predicted)
PSA：76.24000
Density:1.33±0.1 g/cm3(Predicted)
LogP:2.61180

Purity/Quality:

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Technology Process of 3H-Imidazo[4,5-b]pyridine-2-methanol, 3-methyl-5-(phenylthio)-

There total 5 articles about 3H-Imidazo[4,5-b]pyridine-2-methanol, 3-methyl-5-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 172648-62-3
(3-methyl-5-phenylsulfanyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Na₂CO₃ / ethanol / 8 h / 20 °C

2: methanol / 3 h / 20 °C

3: H₂ / 10percent Pd/C / dioxane / 5 h / 80 °C

4: toluene / 4 h / Heating

With hydrogen; sodium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; ethanol; toluene; 1: Amination / 2: Akoxylation / 3: Catalytic hydrogenation / 4: Cyclization;
DOI:10.1021/jm990522t

Reference yield:

: 930-69-8
sodium thiophenolate

: 172648-62-3
(3-methyl-5-phenylsulfanyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 3 h / 20 °C

2: H₂ / 10percent Pd/C / dioxane / 5 h / 80 °C

3: toluene / 4 h / Heating

With hydrogen; 10percent Pd/C; In 1,4-dioxane; methanol; toluene; 1: Akoxylation / 2: Catalytic hydrogenation / 3: Cyclization;
DOI:10.1021/jm990522t

Reference yield:

: 33742-70-0
6-chloro-N-methyl-3-nitropyridin-2-amine

: 172648-62-3
(3-methyl-5-phenylsulfanyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 3 h / 20 °C

2: H₂ / 10percent Pd/C / dioxane / 5 h / 80 °C

3: toluene / 4 h / Heating

With hydrogen; 10percent Pd/C; In 1,4-dioxane; methanol; toluene; 1: Akoxylation / 2: Catalytic hydrogenation / 3: Cyclization;
DOI:10.1021/jm990522t