Naphthalene, 2-(3-fluorophenyl)-

Base Information

• Chemical Name: Naphthalene, 2-(3-fluorophenyl)-
• CAS No.: 174018-64-5
• Molecular Formula: C16H11F
• Molecular Weight: 222.262
• Mol file: 174018-64-5.mol

Synonyms:

Chemical Property of Naphthalene, 2-(3-fluorophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 2-(3-fluorophenyl)-

There total 5 articles about Naphthalene, 2-(3-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

naphthalen-2-yl acetate (1523-11-1) + bromo(3-fluorophenyl)magnesium (17318-03-5) → 2-(3-fluorophenyl)naphthalene (174018-64-5)

Guidance literature:

bromo(3-fluorophenyl)magnesium; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

naphthalen-2-yl acetate; With bis(tricyclohexylphosphine)nickel(II) dichloride; In tetrahydrofuran; N,N-dimethyl acetamide; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.200803814

Reference yield: 63.0%

2-naphthalene carboxylic anhydride (20176-11-8) + 3-fluorophenylboronic acid (768-35-4) → 2-(3-fluorophenyl)naphthalene (174018-64-5)

Guidance literature:

With bis(tricyclohexylphosphine)nickel(II) dichloride; caesium carbonate; tricyclohexylphosphine; In toluene; at 150 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c02266

Reference yield: 55.0%

tert-butyl naphthalen-2-yl(phenyl)carbamate + bromo(3-fluorophenyl)magnesium (17318-03-5) → 2-(3-fluorophenyl)naphthalene (174018-64-5)

Guidance literature:

tert-butyl naphthalen-2-yl(phenyl)carbamate; With bis(tricyclohexylphosphine)nickel(II) dichloride; In tetrahydrofuran; toluene; at 25 ℃; for 0.0333333h; Schlenk technique; Inert atmosphere; Sealed tube;

bromo(3-fluorophenyl)magnesium; In tetrahydrofuran; toluene; at 25 ℃; for 36h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b00242

upstream raw materials:

2-bromonaphthalene

3-fluorophenylboronic acid

naphthalen-2-yl acetate

bromo(3-fluorophenyl)magnesium

Downstream raw materials:

2-(3-fluoro-4-iodophenyl)naphthalene

2-(2',4',5'-trimethylbiphenyl-3-yl)naphthalene

2-fluoro-4-(naphthalen-2-yl)benzaldehyde