1-Piperidinecarboxylic acid, 3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester, (3S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester, (3S)-
CAS No.:174759-65-0
Molecular Formula:C₃₉H₄₄N₄O₇S
Molecular Weight:712.867
Hs Code.:

1-Piperidinecarboxylic acid,
3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth
oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester,
(3S)-

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester, (3S)-

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Technology Process of 1-Piperidinecarboxylic acid, 3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester, (3S)-

There total 8 articles about 1-Piperidinecarboxylic acid, 3-[[[[(2S)-1-[(2S)-2-[(2-naphthalenylsulfonyl)amino]-1-oxo-3-(phenylmeth oxy)propyl]-2-pyrrolidinyl]methyl]amino]carbonyl]-, phenylmethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 174759-65-0
(S)-3-({(S)-1-[(S)-3-Benzyloxy-2-(naphthalene-2-sulfonylamino)-propionyl]-pyrrolidin-2-ylmethyl}-carbamoyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: EDAC; HOBt; NMM / dimethylformamide

2: TFA / CH₂Cl₂ / 0 °C

3: Et₃N / CH₂Cl₂

4: H₂ / 10 percent Pd/C / ethanol

5: EDAC; HOBt; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00664-3

Reference yield:

: 86661-32-7
(S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate

: 174759-65-0
(S)-3-({(S)-1-[(S)-3-Benzyloxy-2-(naphthalene-2-sulfonylamino)-propionyl]-pyrrolidin-2-ylmethyl}-carbamoyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃ / dimethylsulfoxide / 70 °C

2: TFA / CH₂Cl₂ / 0 °C

3: EDAC; HOBt; NMM / dimethylformamide

4: TFA / CH₂Cl₂ / 0 °C

5: Et₃N / CH₂Cl₂

6: H₂ / 10 percent Pd/C / ethanol

7: EDAC; HOBt; NMM / dimethylformamide

With 4-methyl-morpholine; sodium azide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00664-3

Reference yield:

: 168049-26-1
tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate

: 174759-65-0
(S)-3-({(S)-1-[(S)-3-Benzyloxy-2-(naphthalene-2-sulfonylamino)-propionyl]-pyrrolidin-2-ylmethyl}-carbamoyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: TFA / CH₂Cl₂ / 0 °C

2: EDAC; HOBt; NMM / dimethylformamide

3: TFA / CH₂Cl₂ / 0 °C

4: Et₃N / CH₂Cl₂

5: H₂ / 10 percent Pd/C / ethanol

6: EDAC; HOBt; NMM / dimethylformamide

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00664-3