N-(4-Chlorophenyl)-1-cyanoformamide

Base Information

• Chemical Name: N-(4-Chlorophenyl)-1-cyanoformamide
• CAS No.: 15313-45-8
• Molecular Formula: C8H5 Cl N2 O
• Molecular Weight: 180.593
• Hs Code.: 2926909090
• Mol file: 15313-45-8.mol

Synonyms:Formanilide,4'-chloro-1-cyano- (8CI); NSC 369321

Chemical Property of N-(4-Chlorophenyl)-1-cyanoformamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 52.89000
• Density: 1.412g/cm³
• LogP: 1.87508

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Chlorophenyl)-1-cyanoformamide

There total 3 articles about N-(4-Chlorophenyl)-1-cyanoformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(hydroxyimino)-3-oxo-N-(4-chlorophenyl)butanamide (42248-27-1) → (4-chlorophenyl)carbamoyl cyanide (15313-45-8)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; at 80 ℃; for 2h;

DOI:10.1021/ol503643p

Reference yield: 85.0%

1-chloro-4-[(cyanocarbonothioyl)amino]benzene (4999-62-6) → (4-chlorophenyl)carbamoyl cyanide (15313-45-8)

Guidance literature:

With iodine; dimethyl sulfoxide; at 38 ℃; for 19h; Temperature;

DOI:10.1039/d2ra00049k

Reference yield:

→ (4-chlorophenyl)carbamoyl cyanide (15313-45-8)

Guidance literature:

4-Chlor-α-isonitroso-acetanilid, Thionylchlorid, Siedetemp., 45min;

upstream raw materials:

2-(hydroxyimino)-3-oxo-N-(4-chlorophenyl)butanamide

1-chloro-4-[(cyanocarbonothioyl)amino]benzene

Refernces

• 1、 Gao, Yu,Guo, Kai,Guo, Tianfo,Li, Yongqiang,Li, Zhenjiang,Liu, Bo,Yao, Zhiwei,Zhang, Zhihao,Zhu, Yuejia. "4,5-Dioxo-imidazolinium Cation Activation of 1-Acyl-1-carbamoyl Oximes: Access to Cyanoformamides Using Dichloroimidazolidinedione". . . Retrieved 2020/01/31.
• 2、 Baruffini,Borgna,Pagani. "Oxanilic acids and derivatives". . p. 717 - 734. Retrieved 2007/10/06.