2-Amino-7-Benzyl-1H-Purin-6(7H)-One

Base Information

• Chemical Name: 2-Amino-7-Benzyl-1H-Purin-6(7H)-One
• CAS No.: 17495-12-4
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.252
• Mol file: 17495-12-4.mol

Synonyms:AR2216;7-Benzyl-guanin;7-benzylguanine;2-amino-7-benzyl-1,7-dihydro-purin-6-one;2-amino-7-benzyl-3,7-dihydro-6H-purin-6-one;2-amino-7-benzyl-1,7-dihydro-6H-purin-6-one;

Chemical Property of 2-Amino-7-Benzyl-1H-Purin-6(7H)-One

Chemical Property:

• PSA: 90.58000
• LogP: 1.09250

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-7-benzyl-1H-purin-6(7H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-7-Benzyl-1H-Purin-6(7H)-One

There total 20 articles about 2-Amino-7-Benzyl-1H-Purin-6(7H)-One which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

benzyl bromide (100-39-0) + (1'S,2'R,3'S,4'S)-9-<2,3-dihydroxy-4-(hydroxymethyl)cyclopentan-1-yl>guanine (224317-32-2) → 2-amino-7-benzyl-1H-purin-6(7H)-one (17495-12-4)

Guidance literature:

benzyl bromide; (1'S,2'R,3'S,4'S)-9-<2,3-dihydroxy-4-(hydroxymethyl)cyclopentan-1-yl>guanine; In dimethyl sulfoxide; at 20 ℃; for 18h;

With hydrogenchloride; In water; dimethyl sulfoxide; for 0.75h;

Reference yield: 85.8%

benzyl bromide (100-39-0) → 2-amino-7-benzyl-1H-purin-6(7H)-one (17495-12-4) + 7-benzylguanine dihydrochloride

Guidance literature:

With hydrogenchloride; In methanol; acetonitrile;

Reference yield: 85.0%

benzyl bromide (100-39-0) + G (118-00-3) → 2-amino-7-benzyl-1H-purin-6(7H)-one (17495-12-4)

Guidance literature:

benzyl bromide; G; In dimethyl sulfoxide; at 20 ℃; for 24h;

With hydrogenchloride; In dimethyl sulfoxide; at 70 ℃; for 2h;

DOI:10.1055/s-2004-829174

upstream raw materials:

7-benzylguanosine

7-benzyl-2-chloro-1,7-dihydro-purin-6-one

benzyl bromide

2'-Deoxyguanosine

Downstream raw materials:

7-benzylxanthine