N-boc-l-phenylalanine trifluoroethyl ester

Base Information

• Chemical Name: N-boc-l-phenylalanine trifluoroethyl ester
• CAS No.: 176665-91-1
• Molecular Formula: C16H20F3NO4
• Molecular Weight: 347.334
• DSSTox Substance ID: DTXSID201143574
• Nikkaji Number: J1.537.757G

Synonyms:N-boc-l-phenylalanine trifluoroethyl ester;ZICMGMSJNRKDHD-LBPRGKRZSA-N;DTXSID201143574;176665-91-1;N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanine 2,2,2-trifluoroethyl ester

Chemical Property of N-boc-l-phenylalanine trifluoroethyl ester

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 347.13444261
• Heavy Atom Count: 24
• Complexity: 426

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C(=O)OCC(F)(F)F
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC(F)(F)F

Technology Process of N-boc-l-phenylalanine trifluoroethyl ester

There total 1 articles about N-boc-l-phenylalanine trifluoroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2,2-trifluoroethanol (75-89-8) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Phe-OCH2CF3 (176665-91-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo0491298

Reference yield: 81.0%

N-acetylneuraminic acid methyl ester (20298-35-5,22900-11-4,100678-43-1,109121-98-4,109122-00-1,119241-60-0,119241-61-1,119241-62-2) + Boc-Phe-OCH2CF3 (176665-91-1) → (2S,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-3-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-1,2-dihydroxy-propyl]-2,4-dihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester (771577-91-4)

Guidance literature:

With pyridine; 4 A molecular sieve; subtilisin Carlsberg ChiroCLEC-BL; at 20 ℃; for 168h;

DOI:10.1021/jo0491298

Reference yield: 80.0%

glycyl glycine ethyl ester hydrochloride (2087-41-4) + Boc-Phe-OCH2CF3 (176665-91-1) → Boc-Phe-Gly-Gly-OEt (440094-95-1)

Guidance literature:

With MCM-22 immobilized α-chymotrypsin (EC 3.4.21.1); water; triethylamine; In cyclohexane; at 17 - 20 ℃; for 48h;

DOI:10.1055/s-2002-25762

upstream raw materials:

2,2,2-trifluoroethanol

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Boc-Phe-Gly-Gly-OEt

(2S,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-3-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-1,2-dihydroxy-propyl]-2,4-dihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester

17β-(N-t-butyloxycarbonyl-L-phenylalanylamino)estra-1,3,5(10)-trien-3-ol

(2S,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-3-((S)-2-amino-3-phenyl-propionyloxy)-1,2-dihydroxy-propyl]-2,4-dihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 176665-91-1 L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,2,2-trifluoroethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send