Carbamic acid, 1,2-ethanediylbis[methyl-, bis(1,1-dimethylethyl) ester

Base Information

• Chemical Name: Carbamic acid, 1,2-ethanediylbis[methyl-, bis(1,1-dimethylethyl) ester
• CAS No.: 177587-81-4
• Molecular Formula: C14H28N2O4
• Molecular Weight: 288.387

Synonyms:[2-(tert-Butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamic acid tert-butyl ester;

Chemical Property of Carbamic acid, 1,2-ethanediylbis[methyl-, bis(1,1-dimethylethyl) ester

Chemical Property:

• PSA: 59.08000
• LogP: 2.72020

Purity/Quality:

97% ^*data from raw suppliers

Di-tert-butylethane-1,2-diylbis(methylcarbamate) 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Carbamic acid, 1,2-ethanediylbis[methyl-, bis(1,1-dimethylethyl) ester

There total 3 articles about Carbamic acid, 1,2-ethanediylbis[methyl-, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl N,N-dimethylcarbamate (7541-17-5) + sec.-butyllithium (598-30-1) → bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate (177587-81-4) + N-(tert-butyloxycarbonyl)-N-methyl-N-[2-(methyl)butyl]amine

Guidance literature:

tert-butyl N,N-dimethylcarbamate; sec.-butyllithium; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; cyclohexane; at -78 ℃; for 2h;

With copper(l) iodide; lithium chloride; In tetrahydrofuran; hexane; cyclohexane; at -30 ℃; for 0.5h;

With iodine; In tetrahydrofuran; hexane; cyclohexane; at -30 - 20 ℃; for 3h;

Reference yield: 70.0%

t-butyl piperidinecarboxylate (75844-69-8) + tert-butyl pyrrolidine-1-carboxylate (86953-79-9) → bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate (177587-81-4) + [2,2'-bipyrrolidine]-1,1'-dicarboxylic acid bis(1,1-dimethylethyl) ester + 1,1-dimethylethyl-2-[(N-tert-butoxycarbonyl-N-methylamino)methyl]pyrrolidine-1-carboxylate

Guidance literature:

Multistep reaction;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + N,N`-dimethylethylenediamine (110-70-3) → tert-butyl N-methyl-N-<2-(methylamino)ethyl>carbamate (112257-19-9) + bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate (177587-81-4)

Guidance literature:

In dichloromethane; for 2h;

upstream raw materials:

tert-butyl N,N-dimethylcarbamate

sec.-butyllithium

t-butyl piperidinecarboxylate

tert-butyl pyrrolidine-1-carboxylate

Downstream raw materials:

(2-{[hydroxy-(4-hydroxy-phenyl)-acetyl]-methyl-amino}-ethyl)-methyl-carbamic acid tert-butyl ester

carbonic acid {[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-[4-({2-[(3-hydroxy-3-methyl-5-oxo-hexyloxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-phenyl]-methyl ester 4-nitro-phenyl ester

(2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

carbonic acid 4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenyl ester 4-nitro-phenyl ester

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